WormBase Tree Display for Variation: WBVar00088351

WBVar00088351 Evidence: Paper_evidence: WBPaper00004382
  Name: Public_name: ku256
    Other_name: CE33761:p.Trp354Ter
      CE24832:p.Trp357Ter
      C37A2.4a.1:c.1070G>A
      C37A2.4b.1:c.1061G>A
    HGVSg: CHROMOSOME_I:g.6783274G>A
  Sequence_details: SMap: S_parent: Sequence: C37A2
    Flanking_sequences: tggaagttcttatcgtcaagtatattgggt gagtcttgggccaatcacaagtattcaatg
    Mapping_target: C37A2
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00004382
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: MH
    Status: Live
  Affects: Gene: WBGene00000871
    Transcript: C37A2.4a.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: C37A2.4a.1:c.1070G>A
        HGVSp: CE24832:p.Trp357Ter
        cDNA_position: 1085
        CDS_position: 1070
        Protein_position: 357
        Exon_number: 7/10
        Codon_change: tGg/tAg
        Amino_acid_change: W/*
      C37A2.4b.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: C37A2.4b.1:c.1061G>A
        HGVSp: CE33761:p.Trp354Ter
        cDNA_position: 1083
        CDS_position: 1061
        Protein_position: 354
        Exon_number: 7/10
        Codon_change: tGg/tAg
        Amino_acid_change: W/*
  Genetics: Interpolated_map_position: I 1.3176
  Description: Phenotype (19)
    Phenotype_not_observed: WBPhenotype:0000166 Paper_evidence: WBPaper00004382
        Curator_confirmed: WBPerson2021
        Remark: Seam cells in cye-1 mutants fuse at the correct time during the late L4 stage Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00004382
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005753 PATO:0000460 Paper_evidence: WBPaper00004382
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: jcIs1[jam-1::GFP] Paper_evidence: WBPaper00004382
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000354 Paper_evidence: WBPaper00004382
        Curator_confirmed: WBPerson2021
        Remark: Despite fewer division cycles, vulval cells in cye-1 mutants can execute differentiation programs and acquire their correct terminal fates Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00004382
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00004382
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: mgIs21 [lin-11::GFP], ayIs4 [egl-17::GFP] Paper_evidence: WBPaper00004382
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001412 Paper_evidence: WBPaper00004382
        Curator_confirmed: WBPerson2021
        Remark: cye-1 mutants generate relatively normal appearing cuticular structures, termed alae Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00004382
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0007832 PATO:0000460 Paper_evidence: WBPaper00004382
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: jcIs1[jam-1::GFP] Paper_evidence: WBPaper00004382
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00004382
  Method: Substitution_allele