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WormBase Tree Display for Variation: WBVar00000083

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Name Class

WBVar00000083EvidencePaper_evidenceWBPaper00002920
NamePublic_namead1051
Other_nameCE25076:p.Trp312Ter
CE13573:p.Trp133Ter
R11G10.1b.1:c.399G>A
R11G10.1a.1:c.936G>A
HGVSgCHROMOSOME_V:g.13501125C>T
Sequence_detailsSMapS_parentSequenceT10G3
Flanking_sequencestagtgtacaactgacattccgtgagagttggtcgataagagactcagcttcggagtgaaa
Mapping_targetT10G3
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00002920
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (12)
LaboratoryDA
StatusLive
AffectsGeneWBGene00000233
TranscriptR11G10.1b.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR11G10.1b.1:c.399G>A
HGVSpCE13573:p.Trp133Ter
cDNA_position473
CDS_position399
Protein_position133
Exon_number4/7
Codon_changetgG/tgA
Amino_acid_changeW/*
R11G10.1a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR11G10.1a.1:c.936G>A
HGVSpCE25076:p.Trp312Ter
cDNA_position1029
CDS_position936
Protein_position312
Exon_number6/9
Codon_changetgG/tgA
Amino_acid_changeW/*
InteractorWBInteraction000500426
WBInteraction000557980
WBInteraction000557981
WBInteraction000557983
GeneticsInterpolated_map_positionV5.36893
DescriptionPhenotypeWBPhenotype:0000547Paper_evidenceWBPaper00002920
Curator_confirmedWBPerson134
Remarkenhanced by difficult to eat E. coli strainsPaper_evidenceWBPaper00002920
Curator_confirmedWBPerson134
WBPhenotype:0000658Paper_evidenceWBPaper00002920
Curator_confirmedWBPerson134
Remarklacks glutamatergic M3 neurotransmissionPaper_evidenceWBPaper00002920
Curator_confirmedWBPerson134
EQ_annotationsAnatomy_termWBbt:0003754PATO:0000460Paper_evidenceWBPaper00002920
Curator_confirmedWBPerson134
GO_termGO:0061535PATO:0000460Paper_evidenceWBPaper00002920
Curator_confirmedWBPerson134
Molecule_affectedWBMol:00005503PATO:0000460Paper_evidenceWBPaper00002920
Curator_confirmedWBPerson134
WBPhenotype:0001444Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
RemarkAnimals exhibited defective gustatory plasticity of NaCl.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested for response to 25 mM NaCl after various pre-treatments: a 15-min wash in CTX buffer with or without 100 mM NaCl (liquid), or 30 min on a CTX plate with or without 100 mM NaCl, and in the presence or absence of bacteria, 500 mM glycerol, or 3 uL of benzaldehyde.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
WBPhenotype:0001453Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
RemarkAnimals showed reduced avoidance of 1 M NaCl.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
WBPhenotype:0001462Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
RemarkAnimals showed wild-type, or even stronger, chemotaxis to NaCl.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested for response to 25 mM NaCl.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
WBPhenotype:0001817Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
RemarkAnimals exhibited significant reduced starvation-enhanced gustatory plasticity compared to wild type.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
WBPhenotype:0002053Paper_evidenceWBPaper00003954
Curator_confirmedWBPerson134
RemarkSynthetic resistance with avr-14(ad1302)Paper_evidenceWBPaper00003954
Curator_confirmedWBPerson134
Synthetic resistance with avr-14(ad1305)Paper_evidenceWBPaper00003954
Curator_confirmedWBPerson134
synthetic resistance with glc-1(pk54)Paper_evidenceWBPaper00003954
Curator_confirmedWBPerson134
Affected_byMoleculeWBMol:00002786Paper_evidenceWBPaper00003954
Curator_confirmedWBPerson134
Phenotype_assayGenotypeavr-14(ad1302)Paper_evidenceWBPaper00003954
Curator_confirmedWBPerson134
avr-14(ad1305)Paper_evidenceWBPaper00003954
Curator_confirmedWBPerson134
glc-1(pk54)Paper_evidenceWBPaper00003954
Curator_confirmedWBPerson134
WBPhenotype:0002399Paper_evidenceWBPaper00003954
Curator_confirmedWBPerson134
RemarkLoss of M3 neurotransmissionPaper_evidenceWBPaper00003954
Curator_confirmedWBPerson134
Phenotype_not_observedWBPhenotype:0001182Paper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Remarkavr-15(ad1051) mutants had wild-type fat contentPaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentFat content was visualized by Nile red stainingPaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
WBPhenotype:0001811Paper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
RemarkMutants were susceptible to the fat-reducing effects of exogenously administered serotoninPaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentReduced fat content of 5-HT-treated animals was visualized by Nile red staining and confirmed by thin-layer chromatography (TLC) quantitation of total triglycerides extracted from vehicle- and 5-HT-treated worms and by Sudan black fat stainingPaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Reference (11)
RemarkThe correct genotype of the DA1316 strain is avr-14(ad1305) I; avr-15(vu227) glc-1(pk54) V. This strain was incorrectly annotated as avr-14(ad1302) I; avr-15(ad1051) glc-1(pk54) V. when submitted to the CGC.
The correct genotype of the DA1370 strain is avr-15(vu227) glc-1(pk54) V. This strain was incorrectly annotated as avr-15(ad1051) glc-1(pk54) V. when submitted to the CGC.
MethodSubstitution_allele