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| WBPicture0000013088 | Description | Figure 5. Coordination of fat synthesis and breakdown pathways by malonyl-CoA. AcetylCoA is the building block of fatty acids that are assembled into storage triglycerides through step-wise enzymatic processes. Inhibiting delta-9 desaturase activity (SCD-1 in mammals, fat-5, fat-6, and fat-7 in C. elegans) causes accumulation of saturated fatty acids. Consequently, acetylCoA carboxylase (ACC) is inactivated through feedback inhibition. This results in reduced levels of the ACC product malonyl-CoA. Since malonyl-CoA is an inhibitor of carnitine-palmitoyl-transferase (CPT), ACC inhibition results in activation of CPT, allowing uptake of fatty acids into mitochondria where they are broken down via β-oxidation. FAS: fatty acid synthase. | |||
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| Name | FigL.jpg | ||||
| Depict | WBProcess | WBbiopr:00000121 | |||
| Gene | WBGene00001398 | ||||
| WBGene00001397 | |||||
| WBGene00001399 | |||||
| Acknowledgment | Template | From: <Journal_URL> <Article_URL>. Copyright <Publication_year>. | |||
| Publication_year | 2007 | ||||
| Article_URL | DOI | id | 10.1895/wormbook.1.130.1 | ||
| Journal_URL | WormBook | ||||
| Publisher_URL | Caltech | ||||
| Reference | WBPaper00031290 |
