WormBase Tree Display for Interaction: WBInteraction000542766
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| WBInteraction000542766 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003623 | Interactor_type | Trans_regulator | |
| WBGene00016201 | Interactor_type | Trans_regulated | |||
| WBGene00002065 | Interactor_type | Trans_regulated | |||
| WBGene00019767 | Interactor_type | Trans_regulated | |||
| WBGene00021202 | Interactor_type | Trans_regulated | |||
| WBGene00022448 | Interactor_type | Trans_regulated | |||
| WBGene00021876 | Interactor_type | Trans_regulated | |||
| Interaction_summary | "We next measured the changes in the expression of reporter fusions with promoters derived from a total of 14 NHR-25 candidate target genes before and after depletion of NHR-25 in either the larval (Fig. 6, A-Q) or embryonic stage (Fig. 6R). Class 1 and 2 target genes known to be spatially expressed in epidermis were chosen to ensure that at least one NHR-25 peak is located within their promoter sequences (data not shown). Surprisingly, although most of the tested target genes (7 of 14) demonstrated significantly reduced expression, two of them, nekl-3 (Fig. 6, A-D and Q) and idh-1 (Fig. 6Q), showed significantly elevated expression after depletion of NHR-25, indicating both activating and inhibitory roles of NHR-25 in regulating its target activities." | ||||
| Detection_method | Reporter_gene | [C28H8.11p::GFP], [Y17G9B.5p::mCherry] | |||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Does_not_regulate | Life_stage | WBls:0000023 | ||
| Anatomy_term | WBbt:0005733 | ||||
| Paper | WBPaper00044288 | ||||
| Remark | Fig. 6efghmnopq |
