WormBase Tree Display for Interaction: WBInteraction000542465
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| WBInteraction000542465 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003652 | Interactor_type | Trans_regulator | |
| WBGene00002980 | Interactor_type | Trans_regulated | |||
| Variation_interactor | WBVar00250782 | Interactor_type | Trans_regulator | ||
| Interaction_summary | "Under normal conditions GFP::LGG-1 is cytoplasmic and diffuse in the worm's hypodermal seam cells, but under DR conditions, forms puncta which are associated with an increase in autophagy [20]. We observed a significant increase in the average number of GFP::LGG-1 puncta per seam cell in the eat-2 background, and found that nhr-62 RNAi suppressed puncta formation back to wild-type levels, suggesting that nhr-62 modulates autophagy up-regulation under DR (Figure 5D)." | ||||
| Detection_method | Reporter_gene | [GFP::LGG-1] | |||
| Regulation_level | Post_translational | ||||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000041 | ||
| Anatomy_term | WBbt:0005753 | ||||
| Subcellular_localization | puncta | ||||
| Paper | WBPaper00044037 | ||||
| Remark | Fig. 5d |
