WormBase Tree Display for Interaction: WBInteraction000534947
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| WBInteraction000534947 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00016943 | Interactor_type | Trans_regulated | |
| Transgene | WBTransgene00018139 | ||||
| WBGene00003691 | Interactor_type | Trans_regulator | |||
| WBGene00305173 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00145953 | Interactor_type | Trans_regulator | ||
| Interaction_summary | "To validate the RNAi approach, we used mutants of three highly similar nuclear hormone receptor (NHR) paralogs, nhr-68, nhr-101, and nhr-114, which have identical regulatory interaction profiles in the GRN (Table S2). We crossed each mutation into reporter strains where GFP expression is driven by the acdh-1 promoter (Pacdh-1::GFP) or the acdh-2 promoter (Pacdh-2::GFP) and observed very similar effects as we did by RNAi - namely, decreased fluorescence of Pacdh-1::GFP and increased fluorescence of Pacdh2::GFP, in the intestine (Figure 2B)." | ||||
| Detection_method | Reporter_gene | Pacdh-1::GFP | |||
| Transgene | |||||
| Regulation_level | Transcriptional | ||||
| Paper | WBPaper00048645 | ||||
| Remark | Figure 2B |
