WormBase Tree Display for Interaction: WBInteraction000524362
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| WBInteraction000524362 | Interaction_type | Genetic | Enhancement | ||
|---|---|---|---|---|---|
| GI_module_two | Enhancing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00003243 | Interactor_type | Effector | |
| WBGene00006746 | Interactor_type | Affected | |||
| Variation_interactor | WBVar00054402 | Interactor_type | Effector | ||
| WBVar00145224 | Interactor_type | Affected | |||
| Interaction_summary | In unc-6(ev400) single mutants, all ACs attached to the BM at the P6.p 1-cell stage prior to the invasion. The ACs later started to detach from the BM staying afloat in the gonad. The percentage of detached ACs increased to 10% and 15% at the P6.p 2- and 4-cell stages, respectively, suggesting that UNC-6 promotes AC-BM adhesion during AC invasion. In contrast, mig-10(ct41) mutants had no phenotypic defects in AC-BM attachment. However, when mig-10 was removed in unc-6 mutants, AC detachment was observed at the P6.p 1-cell stage, revealing an early requirement for MIG-10B in 215 stabilizing AC-BM attachment . AC detachment was later drastically increased by approximately 4-6 folds at the P6.p 2- and 4-cell stages, indicating a synergistic effect between MIG-10B and UNC-6 on mediating AC-BM adhesion during AC invasion. | ||||
| Throughput | Low_throughput | ||||
| Interaction_phenotype | WBPhenotype:0001652 | ||||
| Paper | WBPaper00045639 |
