WormBase Tree Display for Interaction: WBInteraction000504522

WBInteraction000504522 Interaction_type: Regulatory: Change_of_expression_level
  Interactor: Interactor_overlapping_gene: WBGene00002245 Interactor_type: Trans_regulator
      WBGene00001952 Interactor_type: Trans_regulated
        Expr_pattern: Expr6698
    Variation_interactor: WBVar00241097 Interactor_type: Trans_regulator
  Interaction_summary: In embryos from lag-1/+ mothers, gland expression was unaffected and ectopic expression in 63% of arrested lag-1 larvae was observed. lag-1(RNAi) embryos expressed the hlh-6 reporter in an average of 7-8 cells (Fig. 6B). Wild type embryos have only five gland cells, suggesting that hlh-6 expression is expanded in lag-1(RNAi) embryos. Further more, 3-4 of the expressing cells appeared to be pharyngeal glands, as they had small projections and are clustered together in the embryo. The remaining cells that expressed hlh-6 were located in other regions of the embryo and do not exhibit gland-like projections, suggesting that while they express hlh-6, their identity has not been altered to a gland-like fate. Consistent with this interpretation, expression of another marker of pharyngeal glands (B0507.1::GFP::HIS2B) is not expanded in lag-1(RNAi) embryos and is confined to 4-5 gland-like cells (Fig. 6C).
  Detection_method: Reporter_gene: [hlh-6::yfp]
  Regulation_level: Transcriptional
  Paper: WBPaper00037618