WormBase Tree Display for Interaction: WBInteraction000502674
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| WBInteraction000502674 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001184 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr2950 | ||||
| Transgene | WBTransgene00005114 | ||||
| Construct | WBCnstr00005091 | ||||
| WBGene00001484 | Interactor_type | Trans_regulator | |||
| WBGene00011279 | Interactor_type | Trans_regulator | |||
| WBGene00196888 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00144894 | Interactor_type | Trans_regulator | ||
| WBVar00275354 | Interactor_type | Trans_regulator | |||
| Interaction_summary | RT-PCR analysis revealed that the amount of endogenous egl-15 mRNA isoforms including exon 5A was reduced in the asd-1;fox-1 double mutant. The vulval muscles were off the vulva in the double mutant when observed with reporter constructs. | ||||
| Detection_method | Construct | ||||
| Reporter_gene | [egl-15::gfp::rfp], translational fusion driven by myo-3 promoter. | ||||
| Transgene | |||||
| Regulation_level | Post_transcriptional | ||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0005821 | ||
| Paper | WBPaper00028743 | ||||
| Remark | asd-1; fox-1 double mutants phenocopied the specific loss of function of EGL-15 (5A) isoforms, and that asd-1 and fox-1 were redundantly required for the selection of endogenous egl-15 exon 5A in sex myoblasts. |
