WormBase Tree Display for Gene: WBGene00001484

WBGene00001484 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: fox-1 Person_evidence: WBPerson261
      Sequence_name: T07D1.4
      Molecular_name (12)
      Other_name: CELE_T07D1.4 Accession_evidence: NDB BX284606
      Public_name: fox-1
    DB_info: Database: AceView gene XD66
        WormQTL gene WBGene00001484
        WormFlux gene WBGene00001484
        NDB locus_tag CELE_T07D1.4
        Panther gene CAEEL|WormBase=WBGene00001484|UniProtKB=Q10572
          family PTHR15597
        NCBI gene 180549
        RefSeq protein NM_001330896.3
            NM_001330894.3
            NM_001330895.6
        SwissProt UniProtAcc Q10572
        UniProt_GCRP UniProtAcc Q10572
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: fox
    Allele (199)
    Legacy_information: [C.elegansII] Extra copies of locus lead to dominant XO lethality and feminization. Cloned: 1.8 kb transcript, encodes predicted 415 aa protein with RNP motif. [Hodgkin et al. 1994; CB; TY]
    Strain: WBStrain00035140
      WBStrain00035141
      WBStrain00004643
      WBStrain00050869
    RNASeq_FPKM (74)
    GO_annotation (31)
    Ortholog (46)
    Paralog: WBGene00011279 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00004984 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: fox-1 encodes an RNA-binding protein of the RNA recognition motif (RRM) superfamily of ribonucleic acid binding proteins; during C. elegans development, FOX-1 functions redundantly with other numerator elements to effect proper dosage compensation in the early embryo; in influencing dosage compensation, FOX-1 likely acts via post-transcriptional regulation of xol-1 mRNA levels; in addition to its role in dosage compensation, fox-1 activity is also required for normal male mating behavior; Western analysis and lacZ reporter constructs indicate that FOX-1 is expressed throughout the life cycle, beginning at the 18-20-cell stage of embryogenesis and continuing on through larval stages and into adult hermaphrodites and males; while early embryonic expression of fox-1 is ubiquitous, postembryonic expression is limited to a subset of head and tail neurons. Paper_evidence: WBPaper00003390
          Curator_confirmed: WBPerson1843
          Date_last_updated: 11 Oct 2005 00:00:00
      Automated_description: Enables pre-mRNA intronic binding activity and single-stranded RNA binding activity. Involved in several processes, including intergenic mRNA trans splicing; primary sex determination; and regulation of gene expression. Located in nucleus. Expressed in body wall musculature; intestine; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; hypoplastic left heart syndrome; myotonic dystrophy type 1; and type 2 diabetes mellitus. Is an ortholog of human RBFOX1 (RNA binding fox-1 homolog 1) and RBFOX3 (RNA binding fox-1 homolog 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9906)
      DOID:1682 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9906)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18222)
      DOID:11722 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9906)
      DOID:9955 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9906)
  Molecular_info: Corresponding_CDS: T07D1.4a
      T07D1.4b
      T07D1.4d
    Corresponding_CDS_history: T07D1.4:wp253
    Corresponding_transcript: T07D1.4a.1
      T07D1.4a.2
      T07D1.4a.3
      T07D1.4a.4
      T07D1.4b.1
      T07D1.4d.1
    Other_sequence (14)
    Associated_feature (22)
    Gene_product_binds: WBsf034319
    Transcription_factor: WBTranscriptionFactor000119
  Experimental_info: RNAi_result: WBRNAi00052744 Inferred_automatically: RNAi_primary
      WBRNAi00018356 Inferred_automatically: RNAi_primary
      WBRNAi00065647 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr528
      Expr771
      Expr4886
      Expr8559
      Expr1026008
      Expr1030886
      Expr1156351
      Expr2011873
      Expr2030111
    Drives_construct: WBCnstr00000436
      WBCnstr00000437
      WBCnstr00000438
      WBCnstr00005107
      WBCnstr00012311
      WBCnstr00012424
      WBCnstr00036916
    Construct_product: WBCnstr00000436
      WBCnstr00000437
      WBCnstr00000438
      WBCnstr00005107
      WBCnstr00012424
      WBCnstr00015910
      WBCnstr00036916
    Antibody: WBAntibody00000210
      WBAntibody00001817
      WBAntibody00002413
    Microarray_results (20)
    Expression_cluster (173)
    Interaction (142)
    WBProcess: WBbiopr:00000056
  Map_info: Map: X Position: -15.4447 Error: 0.138215
    Well_ordered
    Positive: Positive_clone: F53B5 Author_evidence: Hodgkin JA
        R04B3 Author_evidence: Hodgkin JA
        T07D1 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4339
      Pos_neg_data: 8772
    Landmark_gene
  Reference (78)
  Method: Gene