WormBase Tree Display for Gene: WBGene00022610
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| WBGene00022610 | SMap | S_parent | Sequence | ZC416 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ltah-1.2 | |||||||
| Sequence_name | ZC416.6 | ||||||||
| Molecular_name | ZC416.6a | ||||||||
| ZC416.6a.1 | |||||||||
| CE28160 | |||||||||
| ZC416.6b | |||||||||
| CE49050 | |||||||||
| ZC416.6b.1 | |||||||||
| Other_name | CELE_ZC416.6 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | ltah-1.2 | ||||||||
| DB_info | Database | AceView | gene | 4E374 | |||||
| WormQTL | gene | WBGene00022610 | |||||||
| WormFlux | gene | WBGene00022610 | |||||||
| NDB | locus_tag | CELE_ZC416.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00022610|UniProtKB=O44183 | |||||||
| family | PTHR45726 | ||||||||
| NCBI | gene | 177123 | |||||||
| RefSeq | protein | NM_067984.7 | |||||||
| NM_001380155.1 | |||||||||
| TrEMBL | UniProtAcc | U4PAP4 | |||||||
| O44183 | |||||||||
| UniProt_GCRP | UniProtAcc | O44183 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:06 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 31 May 2017 14:23:55 | WBPerson2970 | Name_change | CGC_name | ltah-1.2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ltah | ||||||||
| Allele (71) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (34) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | ZC416.6 encodes a protein with similarity to bifunctional leukotriene A4 hydrolases/aminopeptidases; loss of ZC416.6 activity via RNAi results in decreased intestinal dipeptide transport, increased fat storage, and increased free fatty acid uptake, a phenotype that mimics loss-of-function mutations in the PEPT-1 intestinal peptide transporter; the product of ZC416.6 is predicted to regulate PEPT-1 transporter activity via regulation of the levels of intracellular amino acids and ultimately, via regulation of the amount of PEPT-1 present on intestinal cell membranes; large-scale expression studies indicate that ZC416.6 is expressed in the intestine. | Paper_evidence | WBPaper00040287 | |||||
| WBPaper00031006 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 21 Oct 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable aminopeptidase activity and epoxide hydrolase activity. Involved in negative regulation of fatty acid transport; regulation of lipid storage; and regulation of peptide transport. Predicted to be located in cytosol. Is an ortholog of human LTA4H (leukotriene A4 hydrolase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | ZC416.6a | |||||||
| ZC416.6b | |||||||||
| Corresponding_transcript | ZC416.6a.1 | ||||||||
| ZC416.6b.1 | |||||||||
| Other_sequence (36) | |||||||||
| Associated_feature | WBsf995996 | ||||||||
| WBsf995997 | |||||||||
| WBsf995998 | |||||||||
| WBsf1017090 | |||||||||
| WBsf1017091 | |||||||||
| WBsf229906 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Chronogram1589 | ||||||||
| Expr7170 | |||||||||
| Expr10736 | |||||||||
| Expr1016015 | |||||||||
| Expr1039986 | |||||||||
| Expr1162348 | |||||||||
| Expr2008625 | |||||||||
| Expr2026860 | |||||||||
| Drives_construct | WBCnstr00003277 | ||||||||
| WBCnstr00024113 | |||||||||
| Construct_product | WBCnstr00024113 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (217) | |||||||||
| Interaction (52) | |||||||||
| Map_info | Map | IV | Position | -3.1213 | |||||
| Positive | Positive_clone | ZC416 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00040287 | |||||||||
| WBPaper00042257 | |||||||||
| WBPaper00048904 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
