WormBase Tree Display for Gene: WBGene00022492
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| WBGene00022492 | SMap | S_parent | Sequence | Y119D3B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | dss-1 | Person_evidence | WBPerson1839 | |||||
| Sequence_name | Y119D3B.15 | ||||||||
| Molecular_name | Y119D3B.15 | ||||||||
| Y119D3B.15.1 | |||||||||
| CE34396 | |||||||||
| Y119D3B.15.2 | |||||||||
| Other_name | CELE_Y119D3B.15 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | dss-1 | ||||||||
| DB_info | Database | AceView | gene | 3C284 | |||||
| WormQTL | gene | WBGene00022492 | |||||||
| WormFlux | gene | WBGene00022492 | |||||||
| NDB | locus_tag | CELE_Y119D3B.15 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00022492|UniProtKB=Q95Y72 | |||||||
| family | PTHR16771 | ||||||||
| NCBI | gene | 175284 | |||||||
| RefSeq | protein | NM_001384022.2 | |||||||
| SwissProt | UniProtAcc | Q95Y72 | |||||||
| TREEFAM | TREEFAM_ID | TF314699 | |||||||
| UniProt_GCRP | UniProtAcc | Q95Y72 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 21 Jan 2008 09:30:30 | WBPerson2970 | Name_change | CGC_name | dss-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dss | ||||||||
| Allele (59) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Contained_in_operon | CEOP3060 | ||||||||
| Ortholog (26) | |||||||||
| Structured_description | Concise_description | dss-1 encodes the C. elegans ortholog of human DSS1 (deleted in split hand/split foot 1) and Saccharomyces cerevisiae SEM1, subunits of the 26S proteasome regulatory particle; in C. elegans, DSS-1 is an essential protein, required for oogenesis and for embryonic and larval development; in addition, dss-1 appears to be required for proper development and/or function of the intestine and dss-1 may play a role in vulval development and regulation of adult lifespan; although loss of dss-1 activity in C. elegans results in no obvious defects in proteasomal function, dss-1 expression in Saccharomyces cerevisiae can efficiently rescue Sem1 growth defects and partially rescue Sem1 protein degradation defects; a DSS-1::GFP fusion protein is expressed in the intestinal epithelium and head neurons during larval and adult stages; DSS-1::GFP expression is strongest in the nucleus, with more diffuse staining seen in the cytoplasm. | Paper_evidence | WBPaper00031869 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 May 2008 00:00:00 | ||||||||
| Automated_description | Involved in several processes, including intestinal absorption; positive regulation of protein ubiquitination; and vulval development. Located in cytoplasm and nucleus. Expressed in head neurons. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y119D3B.15 | |||||||
| Corresponding_CDS_history | Y119D3B.15:wp101 | ||||||||
| Corresponding_transcript | Y119D3B.15.1 | ||||||||
| Y119D3B.15.2 | |||||||||
| Other_sequence (61) | |||||||||
| Associated_feature | WBsf666558 | ||||||||
| WBsf226188 | |||||||||
| WBsf226189 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr8241 | ||||||||
| Expr8242 | |||||||||
| Expr1027587 | |||||||||
| Expr1039938 | |||||||||
| Expr1159014 | |||||||||
| Expr2011112 | |||||||||
| Expr2029348 | |||||||||
| Drives_construct | WBCnstr00013204 | ||||||||
| Construct_product | WBCnstr00013204 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (88) | |||||||||
| Interaction (19) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| Map_info | Map | III | Position | -22.6273 | Error | 0.006694 | |||
| Positive | Positive_clone | Y119D3B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00027753 | ||||||||
| WBPaper00031869 | |||||||||
| WBPaper00033351 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041831 | |||||||||
| WBPaper00045116 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00059748 | |||||||||
| WBPaper00061947 | |||||||||
| WBPaper00065621 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
