WormBase Tree Display for Gene: WBGene00022159

WBGene00022159 SMap: S_parent: Sequence: Y71G12B
  Identity: Version: 2
    Name: CGC_name: mppa-1 Paper_evidence: WBPaper00027699
      Sequence_name: Y71G12B.24
      Molecular_name: Y71G12B.24a
        Y71G12B.24a.1
        CE48095
        Y71G12B.24b
        CE49612
        Y71G12B.24b.1
      Other_name: CELE_Y71G12B.24 Accession_evidence: NDB BX284601
      Public_name: mppa-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:05 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 28 Jul 2006 09:57:21 WBPerson2970 Name_change: CGC_name: mppa-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mppa
    Allele (443)
    RNASeq_FPKM (74)
    GO_annotation: 00089114
      00089115
      00089116
      00089117
      00089118
      00089119
      00089120
      00089121
      00126335
    Ortholog (40)
    Paralog: WBGene00013880 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018963 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011679 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012158 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013492 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015360 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015481 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018426 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020757 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Contributes to metalloendopeptidase activity. Involved in proteolysis. Part of mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 2. Is an ortholog of human PMPCA (peptidase, mitochondrial processing subunit alpha). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080061 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18667)
  Molecular_info: Corresponding_CDS: Y71G12B.24a
      Y71G12B.24b
    Corresponding_CDS_history: Y71G12B.24:wp236
    Corresponding_transcript: Y71G12B.24a.1
      Y71G12B.24b.1
    Other_sequence (52)
    Associated_feature: WBsf218988
  Experimental_info: RNAi_result: WBRNAi00117122 Inferred_automatically: RNAi_primary
      WBRNAi00102819 Inferred_automatically: RNAi_primary
      WBRNAi00058211 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1028092
      Expr1039763
      Expr1161627
      Expr2013669
      Expr2031903
    Antibody: WBAntibody00001110
    Microarray_results (16)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-35_downregulated
      WBPaper00040560:hpl-2_embryo_downregulated
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00046499:AMPK_regulated
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00046691:P1_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049954:BPS_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:NMDA-neuron_enriched
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056165:mina-1(ok1521)_upregulated_protein
      WBPaper00056284:ints-5(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060909:atfs-1(et18)_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:pm7
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:atad-3-mpst-1
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00025032:cluster_36
      WBPaper00029437:dcr-1_downregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:FedUp
      WBPaper00034739:TreatmentAffectedGenes
      WBPaper00035227:heat_shock_regulated
      WBPaper00035560:ahr-1_downregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036286:Pattern_E
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00049538:atfs-1(et18)_upregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
    Interaction (42)
  Map_info: Map: I Position: -13.0232 Error: 0.046413
    Positive: Positive_clone: Y71G12B Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027699
    WBPaper00030701
    WBPaper00038491
    WBPaper00048759
    WBPaper00055090
    WBPaper00064339
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene