WormBase Tree Display for Gene: WBGene00021348
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| WBGene00021348 | SMap | S_parent | Sequence | Y37E3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | moag-4 | Person_evidence | WBPerson1519 | |||||
| WBPerson2582 | |||||||||
| Sequence_name | Y37E3.4 | ||||||||
| Molecular_name | Y37E3.4 | ||||||||
| Y37E3.4.1 | |||||||||
| CE26771 | |||||||||
| Other_name | CELE_Y37E3.4 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | moag-4 | ||||||||
| DB_info | Database | AceView | gene | 1C633 | |||||
| WormQTL | gene | WBGene00021348 | |||||||
| WormFlux | gene | WBGene00021348 | |||||||
| NDB | locus_tag | CELE_Y37E3.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00021348|UniProtKB=Q9BKU8 | |||||||
| family | PTHR13596 | ||||||||
| NCBI | gene | 171764 | |||||||
| RefSeq | protein | NM_001393007.1 | |||||||
| SwissProt | UniProtAcc | Q9BKU8 | |||||||
| TREEFAM | TREEFAM_ID | TF330718 | |||||||
| UniProt_GCRP | UniProtAcc | Q9BKU8 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:04 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 23 Aug 2010 13:37:40 | WBPerson2970 | Name_change | CGC_name | moag-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | moag | ||||||||
| Allele (18) | |||||||||
| Strain (14) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00091687 | ||||||||
| 00091688 | |||||||||
| 00091689 | |||||||||
| 00091690 | |||||||||
| 00091691 | |||||||||
| 00091692 | |||||||||
| 00091693 | |||||||||
| 00091694 | |||||||||
| Contained_in_operon | CEOP1028 | ||||||||
| Ortholog (28) | |||||||||
| Structured_description | Concise_description | moag-4 encodes a small protein that is evolutionarily highly conserved, containing a 4F5 domain predicted to have a helix-loop-helix secondary structure, moag-4 is orthologous to human SERF1A and SERF2 (OMIM: 603011, 605054); MOAG-4 is a general regulator of protein aggregation and proteotoxicity but it does not act on all disease-associated aggregation-prone proteins; MOAG-4 and human SERF proteins regulate polyglutamine aggregation in a similar manner; moag-4 acts cell autonomously on protein aggregation and presence of MOAG-4 drives aggregation-prone proteins toward a compact conformation preceding the formation of aggregates; MOAG-4 may drive aggregation by acting on soluble aggregation-prone proteins directly or by regulating a signaling pathway; MOAG-4 enhances aggregation either downstream or in parallel to hsf-1 and daf-16; presence of MOAG-4 enhances the toxicity of polyglutamine; MOAG::4Cherry is excluded from Polyglutamine aggregates. | Paper_evidence | WBPaper00037072 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 15 Jun 2011 00:00:00 | ||||||||
| Automated_description | Involved in protein destabilization. Located in cytosol and nucleus. Is an ortholog of human SERF2 (small EDRK-rich factor 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y37E3.4 | |||||||
| Corresponding_transcript | Y37E3.4.1 | ||||||||
| Other_sequence (80) | |||||||||
| Associated_feature | WBsf643077 | ||||||||
| WBsf656006 | |||||||||
| WBsf217271 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00110185 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00055937 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9106 | ||||||||
| Expr1024902 | |||||||||
| Expr1039316 | |||||||||
| Expr1159455 | |||||||||
| Expr2013636 | |||||||||
| Expr2031870 | |||||||||
| Drives_construct | WBCnstr00007435 | ||||||||
| Construct_product | WBCnstr00007435 | ||||||||
| WBCnstr00007436 | |||||||||
| WBCnstr00013725 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (90) | |||||||||
| Interaction | WBInteraction000500420 | ||||||||
| WBInteraction000500421 | |||||||||
| WBInteraction000500423 | |||||||||
| WBInteraction000500424 | |||||||||
| WBInteraction000581211 | |||||||||
| WBInteraction000582202 | |||||||||
| Map_info | Map | I | Position | -12.1489 | Error | 0.033257 | |||
| Positive | Positive_clone | Y37E3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (9) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
