| WBGene00020230 | SMap | S_parent | Sequence | T05A8 |
|---|
| Identity (6) |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | nep |
| | Allele (278) |
| | Strain | WBStrain00022691 |
| | | WBStrain00022693 |
| | | WBStrain00032820 |
| | RNASeq_FPKM (74) |
| | GO_annotation (18) |
| | Ortholog (47) |
| | Paralog (24) |
| | Structured_description | Concise_description | T05A8.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; while T05A8.4 is an ortholog of mammalian neutral endopeptidase (NEP), expressed on the brush-border membranes of kidney; more generally, T05A8.4 falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes). | Paper_evidence | WBPaper00004584 |
| | | | | | WBPaper00013276 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable metalloendopeptidase activity. Involved in olfactory learning and regulation of chemotaxis. Located in cell surface. Expressed in GLR and body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; X-linked dominant hypophosphatemic rickets; and cerebellar ataxia type 43. Is an ortholog of human MME (membrane metalloendopeptidase) and MMEL1 (membrane metalloendopeptidase like 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7154) |
| | | DOID:9246 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7154) |
| | | DOID:0111745 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7154) |
| | | DOID:10976 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7154) |
| | | DOID:0050445 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8918) |
| | | DOID:0110160 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7154) |
| | | DOID:824 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7154) |
| Molecular_info | Corresponding_CDS | T05A8.4 |
| | Corresponding_CDS_history | T05A8.4a:wp264 |
| | | T05A8.4b:wp264 |
| | Corresponding_transcript | T05A8.4.1 |
| | Other_sequence (21) |
| | Associated_feature (17) |
| Experimental_info | RNAi_result | WBRNAi00035174 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00035173 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00052456 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089146 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00052455 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00018193 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr9142 |
| | | Expr9143 |
| | | Expr1016088 |
| | | Expr1038804 |
| | | Expr1156079 |
| | | Expr2013972 |
| | | Expr2032211 |
| | Drives_construct | WBCnstr00013743 |
| | | WBCnstr00013744 |
| | | WBCnstr00025281 |
| | Construct_product | WBCnstr00013744 |
| | | WBCnstr00025281 |
| | Microarray_results (30) |
| | Expression_cluster | WBPaper00005700:secreted_protein |
| | | WBPaper00030922:glycosylated_protein |
| | | WBPaper00033070:Rhine_upregulated |
| | | WBPaper00037950:bodywall-muscle_CoreEnriched |
| | | WBPaper00037950:bodywall-muscle_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00046691:P1_enriched |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050599:nicotine(0.01mM)_upregulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051461:pig-1(gm344)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:F49E2.5_8378-anc-1_2769 |
| | | WBPaper00061651:PVN_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_upregulated_protein |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:7_1 |
| | | WBPaper00065841:19_0 |
| | | WBPaper00065841:20_1 |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:32_0 |
| | | WBPaper00065841:46_0 |
| | | WBPaper00065841:92_0 |
| | | WBPaper00065841:108_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065841:140_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066085:sin-3(tm1276)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_1_6 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00032948:StarveUp3 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00038172:tax-6null_up_regulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041002:HF_11d_0.2mM_Down |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00049311:sAg-MNP_regulated |
| | | WBPaper00050538:Fasting_upregulated |
| | | WBPaper00050538:Fasting_upregulated_cholesterol-dependent |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction | WBInteraction000031218 |
| | | WBInteraction000244220 |
| | | WBInteraction000380973 |
| | | WBInteraction000392441 |
| | | WBInteraction000469209 |
| | | WBInteraction000469309 |
| | | WBInteraction000521695 |
| | | WBInteraction000521698 |
| | | WBInteraction000553913 |
| Map_info | Map | II | Position | -11.8249 | Error | 0.020198 |
| | Positive | Positive_clone | T05A8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (11) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
