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WormBase Tree Display for Gene: WBGene00019492

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Name Class

WBGene00019492SMapS_parentSequenceK07E3
IdentityVersion1
NameSequence_nameK07E3.4
Molecular_nameK07E3.4a
K07E3.4a.1
CE18020
K07E3.4b
K07E3.4b.1
Other_nameCELE_K07E3.4Accession_evidenceNDBBX284606
Public_nameK07E3.4
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:01WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
StatusLive
Gene_infoBiotypeSO:0001217
Allele (59)
StrainWBStrain00002274
RNASeq_FPKM (74)
GO_annotation00071098
00071099
00071100
00071101
00124330
00124331
Ortholog (55)
ParalogWBGene00000929Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionAutomated_descriptionPredicted to enable ATP binding activity and formate-tetrahydrofolate ligase activity. Predicted to be involved in tetrahydrofolate interconversion. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; cleft lip; and developmental cardiac valvular defect. Is an ortholog of human MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0080633Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7432)
DOID:7693Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7432)
DOID:14250Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7432)
DOID:0080074Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:21055,HGNC:7432)
DOID:9296Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7432)
DOID:6419Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7432)
DOID:0080016Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7432)
DOID:674Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7432)
Molecular_infoCorresponding_CDSK07E3.4a
K07E3.4b
Corresponding_CDS_historyK07E3.4:wp19
Corresponding_transcriptK07E3.4a.1
K07E3.4b.1
Other_sequence (110)
Associated_featureWBsf654186
WBsf654187
WBsf670803
WBsf670804
WBsf670805
WBsf237641
WBsf237642
WBsf237643
Experimental_infoRNAi_resultWBRNAi00016732Inferred_automaticallyRNAi_primary
WBRNAi00050169Inferred_automaticallyRNAi_primary
Expr_patternChronogram454
Expr6351
Expr1025644
Expr1038424
Expr1153864
Expr2004863
Expr2023084
Drives_constructWBCnstr00002974
WBCnstr00025799
Construct_productWBCnstr00025799
Microarray_results (20)
Expression_clusterWBPaper00028451:Low_abundance_spermatogenesis_enriched
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032031:DConiospora_downregulated_cDNA_12h
WBPaper00032425:down_in_alg-1
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035963:S.aureus_8h_upregulated
WBPaper00037047:aging_accelerated_insoluble_protein
WBPaper00037047:insoluble_protein
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:coelomocytes_embryo_enriched
WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_embryo_enriched
WBPaper00037950:intestine_embryo_SelectivelyEnriched
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038061:aldicarb_downregulated
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00041097:pgl-1_upregulated
WBPaper00044128:DietaryRestriction_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_upregulated_HeatShock
WBPaper00045314:S.aureus-induced_N2
WBPaper00045417:128Q-huntingtin_downreglated
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00045774:clk-1_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_downregulated
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050599:nicotine(0.01mM)_upregulated
WBPaper00050599:nicotine(1mM)_upregulated
WBPaper00050636:aging_regulated_insoluble_protein
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:intestine_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
WBPaper00053599:female_vs_male_upregulated
WBPaper00053615:SMO-1_target
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057288:Cold_downregulated_protein
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00058969:RIS_depleted
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059816:crh-1(n3315)_downrgulated
WBPaper00060100:SiNP_downregulated_mRNA
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
WBPaper00060526:plp-1(ok2155)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:Coelomocyte
WBPaper00061340:hmc_and_homolog
WBPaper00061340:hmc_homolog
WBPaper00061340:hyp4_hyp5_hyp6
WBPaper00061340:T
WBPaper00061466:nath-10(icb99)_upregulated
WBPaper00061527:dhs-28_22199-acs-14
WBPaper00061651:CAN_enriched
WBPaper00061651:Coelomocyte_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:hsf-1(RNAi)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064871:hypoxia_downregulated_F3
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065841:33_0
WBPaper00065841:33_1
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4386_cluster_1_1
cgc4489_group_10
WBPaper00025032:cluster_10
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00027342:alpha-Synuclein(A53T)_downregulated
WBPaper00031832:slr-2_regulated
WBPaper00032948:StarveUp2
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00035873:osm-11_regulated
WBPaper00036123:Cadmium_regulated
WBPaper00037695:LD_3-day
WBPaper00037695:WC_5-day
WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041960:daf-16_fasting_upregulated
WBPaper00041960:jun-1_fasting_upregulated
WBPaper00041960:kgb-1_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated_9hto12h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00042178:hlh-29(tm284)_upregulated
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00044091:Bpseudomallei_repressed_8h
WBPaper00044091:Bpseudomallei_repressed_12h
WBPaper00045865:biofilm_upregulated_A
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
WBPaper00048989:N2_allantoin_downregulated
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00050538:Fasting_upregulated
WBPaper00050538:Fasting_upregulated_cholesterol-dependent
WBPaper00053236:daf-16(mgDF50)_regulated_Starved
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00053688:E.faecalis_upregulated
WBPaper00053688:E.faecium_upregulated
[cgc5767]:cluster_2
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
Interaction (127)
Map_infoPositivePositive_cloneK07E3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Interpolated_map_positionX-0.598083
ReferenceWBPaper00032322
WBPaper00038491
WBPaper00055090
WBPaper00065331
MethodGene