WormBase Tree Display for Gene: WBGene00019476

WBGene00019476 SMap: S_parent: Sequence: K07C11
  Identity: Version: 2
    Name: CGC_name: timp-1 Person_evidence: WBPerson2644
      Sequence_name: K07C11.3
      Molecular_name: K07C11.3
        K07C11.3.1
        CE29510
      Other_name: CELE_K07C11.3 Accession_evidence: NDB BX284605
      Public_name: timp-1
    DB_info: Database: AceView gene 5I687
        WormQTL gene WBGene00019476
        WormFlux gene WBGene00019476
        NDB locus_tag CELE_K07C11.3
        Panther gene CAEEL|WormBase=WBGene00019476|UniProtKB=Q21267
          family PTHR11844
        NCBI gene 179199
        RefSeq protein NM_072714.8
        TREEFAM TREEFAM_ID TF317409
        TrEMBL UniProtAcc Q21267
        UniProt_GCRP UniProtAcc Q21267
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:01 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 05 Sep 2017 13:25:30 WBPerson2970 Name_change: CGC_name: timp-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: timp
    Allele (15)
    Strain: WBStrain00051251
    RNASeq_FPKM (74)
    GO_annotation: 00071022
      00071023
      00071024
      00071025
      00071026
      00071027
      00071028
      00124320
    Ortholog (27)
    Paralog: WBGene00019478 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of membrane protein ectodomain proteolysis and response to organic substance. Predicted to be located in extracellular matrix and extracellular space. Expressed in several structures, including coelomocyte; gonad; head neurons; nerve ring; and vulval cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Duchenne muscular dystrophy; Huntington's disease; artery disease (multiple); and carcinoma (multiple). Is an ortholog of human TIMP2 (TIMP metallopeptidase inhibitor 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (16)
  Molecular_info: Corresponding_CDS: K07C11.3
    Corresponding_transcript: K07C11.3.1
    Other_sequence: CJC14055_1
    Associated_feature: WBsf646992
      WBsf232076
  Experimental_info: RNAi_result: WBRNAi00050122 Inferred_automatically: RNAi_primary
      WBRNAi00034052 Inferred_automatically: RNAi_primary
      WBRNAi00016701 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr14699
      Expr14701
      Expr1012009
      Expr1038413
      Expr1153823
      Expr2004845
      Expr2023066
    Drives_construct: WBCnstr00025812
      WBCnstr00040773
      WBCnstr00040776
    Construct_product: WBCnstr00025812
      WBCnstr00040773
    Microarray_results (20)
    Expression_cluster: WBPaper00030922:glycosylated_protein
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045521:Spermatogenic
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00049905:Age_variant_expression
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053792:Ochrobactrum_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053810:sod-2(ok1030)_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055648:vulva-uterus_expressed
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00061340:hmc
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061527:W01F3.2_1554-Y106G6D.8
      WBPaper00061651:CEPsh_enriched
      WBPaper00061651:hmc_enriched
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00062590:Aging_downregulated_body-wall-muscle
      WBPaper00062715:blmp-1(s71)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065623:103
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:7_0
      WBPaper00065841:7_1
      WBPaper00065841:7_2
      WBPaper00065841:7_3
      WBPaper00065841:37_0
      WBPaper00065841:110_0
      WBPaper00065841:110_1
      WBPaper00065841:141_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_3_3
      cgc4489_group_9
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027111:eri-1(mg366)_upregulated
      WBPaper00027111:rde-3(ne298)_upregulated
      WBPaper00029437:rde-4_upregulated
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031662:spaceflight_downregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp3
      WBPaper00036286:Pattern_D
      WBPaper00037695:LD_3-day
      WBPaper00038172:aak-2overexpression_down_regulated
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-4317_vs_OP50_10d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_downregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
    Interaction (125)
  Map_info: Map: V Position: 1.20444
    Positive: Positive_clone: K07C11 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00056623
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene