WormBase Tree Display for Gene: WBGene00019478
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| WBGene00019478 | SMap | S_parent | Sequence | K07C11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cri-2 | Person_evidence | WBPerson16 | |||||
| Sequence_name | K07C11.5 | ||||||||
| Molecular_name | K07C11.5 | ||||||||
| K07C11.5.1 | |||||||||
| CE07348 | |||||||||
| Other_name | 5I683 | Accession_evidence | EMBL | AF303253 | |||||
| tag-225 | Person_evidence | WBPerson201 | |||||||
| CELE_K07C11.5 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | cri-2 | ||||||||
| DB_info | Database | AceView | gene | 5I683 | |||||
| WormQTL | gene | WBGene00019478 | |||||||
| WormFlux | gene | WBGene00019478 | |||||||
| NDB | locus_tag | CELE_K07C11.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00019478|UniProtKB=Q21265 | |||||||
| family | PTHR11844 | ||||||||
| NCBI | gene | 179197 | |||||||
| RefSeq | protein | NM_072712.8 | |||||||
| SwissProt | UniProtAcc | Q21265 | |||||||
| UniProt_GCRP | UniProtAcc | Q21265 | |||||||
| OMIM | gene | 188826 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 07 May 2008 10:04:34 | WBPerson2970 | Name_change | CGC_name | cri-2 | ||||
| Other_name | tag-225 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cri | ||||||||
| Allele (14) | |||||||||
| Strain | WBStrain00002668 | ||||||||
| WBStrain00031717 | |||||||||
| WBStrain00036008 | |||||||||
| WBStrain00036108 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (35) | |||||||||
| Paralog | WBGene00019476 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | K07C11.5 is orthologous to the human gene SIMILAR TO TISSUE INHIBITOR OF METALLOPROTEINASE 3 (SORSBY FUNDUS DYSTROPHY, PSEUDOINFLAMMATORY) (TIMP3; OMIM:188826), which when mutated leads to disease. | Curator_confirmed | WBPerson1823 | |||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 Aug 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of membrane protein ectodomain proteolysis and response to organic substance. Predicted to be located in extracellular matrix and extracellular space. Expressed in several structures, including enteric muscle; gonad; hyp12; nerve ring; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Duchenne muscular dystrophy; artery disease (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human TIMP2 (TIMP metallopeptidase inhibitor 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (39) | ||||||||
| Molecular_info | Corresponding_CDS | K07C11.5 | |||||||
| Corresponding_transcript | K07C11.5.1 | ||||||||
| Other_sequence (26) | |||||||||
| Associated_feature | WBsf232074 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00050124 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00075833 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089115 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033552 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00016703 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1148 | ||||||||
| Expr4930 | |||||||||
| Expr6345 | |||||||||
| Expr14700 | |||||||||
| Expr1026268 | |||||||||
| Expr1038415 | |||||||||
| Expr1153825 | |||||||||
| Expr2010531 | |||||||||
| Expr2028771 | |||||||||
| Drives_construct | WBCnstr00003210 | ||||||||
| WBCnstr00012343 | |||||||||
| WBCnstr00037825 | |||||||||
| WBCnstr00040779 | |||||||||
| Construct_product | WBCnstr00037825 | ||||||||
| WBCnstr00040779 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (20) | |||||||||
| Map_info | Map | V | Position | 1.196 | Error | 0.008873 | |||
| Positive | Positive_clone | K07C11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4928 | |||||||
| 4702 | |||||||||
| 5659 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00031003 | ||||||||
| WBPaper00031865 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041771 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00052194 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056623 | |||||||||
| WBPaper00062715 | |||||||||
| WBPaper00063790 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
