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WormBase Tree Display for Gene: WBGene00019427

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Name Class

WBGene00019427SMapS_parentSequenceK06A1
IdentityVersion2
NameCGC_nameatg-16.2Person_evidenceWBPerson649
Sequence_nameK06A1.5
Molecular_nameK06A1.5
K06A1.5.1
CE39948
Other_nameCELE_K06A1.5Accession_evidenceNDBBX284602
Public_nameatg-16.2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:01WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
229 Feb 2008 11:29:01WBPerson2970Name_changeCGC_nameatg-16.2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classatg
Allele (30)
StrainWBStrain00033048
RNASeq_FPKM (74)
GO_annotation (18)
Contained_in_operonCEOP2729
Ortholog (36)
ParalogWBGene00017178Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
Structured_descriptionConcise_descriptionatg-16.2 encodes a divergent ortholog of the autophagic budding yeast protein Atg16p, and of human ATG16L1 (OMIM:610767, associated with Crohndisease) and ATG16L2; ATG-16.2 is paralogous to ATG-16.1; ATG-16.2 hasno obvious function in mass RNAi assays.Paper_evidenceWBPaper00031597
Curator_confirmedWBPerson567
Date_last_updated16 Mar 2008 00:00:00
Automated_descriptionInvolved in defense response to Gram-positive bacterium; gamete generation; and macroautophagy. Located in cytoplasm. Expressed in body wall musculature; embryonic cell; intestine; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Is an ortholog of human ATG16L1 (autophagy related 16 like 1) and ATG16L2 (autophagy related 16 like 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0110885Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:21498)
Molecular_infoCorresponding_CDSK06A1.5
Corresponding_CDS_historyK06A1.5:wp155
Corresponding_transcriptK06A1.5.1
Other_sequenceCJC03860_1
CR11609
CR01569
Oden_isotig18752
CRC02235_1
ES739747.1
CRC00622_1
HBC05383_1
CR05733
Associated_featureWBsf650147
WBsf665614
WBsf223177
WBsf223178
WBsf223179
Experimental_infoRNAi_resultWBRNAi00016651Inferred_automaticallyRNAi_primary
WBRNAi00092352Inferred_automaticallyRNAi_primary
WBRNAi00081157Inferred_automaticallyRNAi_primary
WBRNAi00102245Inferred_automaticallyRNAi_primary
WBRNAi00050018Inferred_automaticallyRNAi_primary
WBRNAi00092351Inferred_automaticallyRNAi_primary
WBRNAi00034001Inferred_automaticallyRNAi_primary
Expr_patternExpr11435
Expr1014835
Expr1038392
Expr1153711
Expr2009488
Expr2027725
Drives_constructWBCnstr00025846
Construct_productWBCnstr00019037
WBCnstr00025846
Microarray_results (20)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00037946:LIN-39_interacting
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:coelomocytes_embryo_enriched
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:hypodermis_larva_enriched
WBPaper00037950:PVD-OLL-neurons_larva_enriched
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
WBPaper00044736:flat_dev_expression
WBPaper00045314:S.aureus-induced_N2
WBPaper00045521:Oogenic
WBPaper00045774:clk-1_upregulated
WBPaper00045861:wdr-5(ok1417)_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049177:rpn-10(ok1865)_upregulated
WBPaper00049217:TCER-1_downregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00050094:mes-2(bn11)_upregulated
WBPaper00050094:mes-6(bn66)_upregulated
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00051257:Levamisole_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster2
WBPaper00053599:female_vs_male_upregulated
WBPaper00053599:mitosis_vs_meiosis_downregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055482:Tunicamycin_upregulated
WBPaper00056039:ptrn-1(tm5597)_upregulated
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056161:hermaphrodite_enriched_siRNA
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056855:his-72(uge40)_upregulated
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_upregulated_endo-siRNA_targets
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058691:set-2(bn129)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00061340:ADL_parent
WBPaper00061340:Parents_of_U_F_B_DVA
WBPaper00061340:Parent_of_K_Kprime
WBPaper00061340:RIS
WBPaper00061340:URA_parent
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061527:bath-38-Y105E8B.7
WBPaper00061753:csr-1(tor159)_upregulated_25C
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
WBPaper00064315:mes-3(bn199)_upregulated_EGCs
WBPaper00064315:mes-3(bn199)_upregulated_PGCs
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064716:paraquat_upregulated
WBPaper00064789:Day12_vs_Day1_upregulated_neuron
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066062:xrep-4(lax137)_upregulated
cgc4489_group_9
WBPaper00025032:cluster_58
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00032948:StarveUp2
WBPaper00034757:up_by_oxidative_stress
WBPaper00035873:dpy-9_regulated
WBPaper00035905:FBF-1_Associated
WBPaper00036286:Pattern_F
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00038231:Cry5B_2-fold_upregulated
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041960:daf-16_fasting_upregulated
WBPaper00041960:jun-1_fasting_upregulated
WBPaper00041960:kgb-1_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated_9hto12h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00042178:hlh-29(tm284)_upregulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00047021:MWCNT_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
Interaction (34)
Map_infoMapIIPosition-0.237977Error0.00254
PositivePositive_cloneK06A1Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (20)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene