WormBase Tree Display for Gene: WBGene00019126
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| WBGene00019126 | SMap | S_parent | Sequence | F59E12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | sam-4 | Paper_evidence | WBPaper00045884 | |||||
| Person_evidence | WBPerson451 | ||||||||
| Sequence_name | F59E12.11 | ||||||||
| Molecular_name | F59E12.11 | ||||||||
| F59E12.11.1 | |||||||||
| CE28570 | |||||||||
| F59E12.11.2 | |||||||||
| Other_name | F59E12.d | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| F59E12.c | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| F59E12.n | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_F59E12.11 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | sam-4 | ||||||||
| DB_info | Database | AceView | gene | 2F938 | |||||
| WormQTL | gene | WBGene00019126 | |||||||
| WormFlux | gene | WBGene00019126 | |||||||
| NDB | locus_tag | CELE_F59E12.11 | |||||||
| Panther | gene | CAEEL|EnsemblGenome=WBGene00019126|UniProtKB=O01902 | |||||||
| family | PTHR31634 | ||||||||
| NCBI | gene | 173955 | |||||||
| RefSeq | protein | NM_001381430.3 | |||||||
| TREEFAM | TREEFAM_ID | TF316379 | |||||||
| TrEMBL | UniProtAcc | O01902 | |||||||
| UniProt_GCRP | UniProtAcc | O01902 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 12 Nov 2014 15:10:23 | WBPerson2970 | Name_change | CGC_name | sam-4 | ||||
| 3 | 06 Mar 2018 14:46:54 | WBPerson4025 | Event | Split_into | WBGene00302971 | ||||
| Split_into | WBGene00302971 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sam | ||||||||
| Allele (24) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Contained_in_operon | CEOP2198 | ||||||||
| CEOP5593 | |||||||||
| Ortholog (33) | |||||||||
| Structured_description | Concise_description | sam-4 encodes a novel protein orthologous to human LOH12CR1, deletions of which have been associated with acute lymphoblastic leukemia; SAM-4 activity is required cell autonomously to maintain synaptic vesicle transport processivity; in regulating synaptic vesicle tranport, SAM-4 functions together with the UNC-104 kinesin motor protein and SYD-2/liprin-alpha; SAM-4 is broadly expressed in the nervous system where it localizes primarily to the anterior nerve ring and, subcellularly, to synaptic vesicle membranes. | Paper_evidence | WBPaper00045884 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Dec 2014 00:00:00 | ||||||||
| Automated_description | Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including multicellular organismal reproductive process; positive regulation of anterograde synaptic vesicle transport; and positive regulation of pharyngeal pumping. Located in synaptic vesicle membrane. Expressed in nerve ring. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Is an ortholog of human BORCS5 (BLOC-1 related complex subunit 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17950) | ||||
| Molecular_info | Corresponding_CDS | F59E12.11 | |||||||
| Corresponding_CDS_history | F59E12.11a:wp264 | ||||||||
| F59E12.11b:wp264 | |||||||||
| Corresponding_transcript | F59E12.11.1 | ||||||||
| F59E12.11.2 | |||||||||
| Corresponding_transcript_history | F59E12.11c:wp264 | ||||||||
| Other_sequence | EY463123.1 | ||||||||
| CJC12832_1 | |||||||||
| CBC16884_1 | |||||||||
| Associated_feature | WBsf650074 | ||||||||
| WBsf650075 | |||||||||
| WBsf650076 | |||||||||
| WBsf223077 | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern | Expr12013 | ||||||||
| Expr1010547 | |||||||||
| Expr1038256 | |||||||||
| Expr1152947 | |||||||||
| Expr2015584 | |||||||||
| Expr2033819 | |||||||||
| Drives_construct | WBCnstr00019746 | ||||||||
| WBCnstr00019749 | |||||||||
| WBCnstr00026043 | |||||||||
| Construct_product | WBCnstr00019745 | ||||||||
| WBCnstr00019746 | |||||||||
| WBCnstr00019747 | |||||||||
| WBCnstr00019749 | |||||||||
| WBCnstr00026043 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (97) | |||||||||
| Interaction (44) | |||||||||
| Map_info | Map | II | Position | -0.993749 | |||||
| Positive | Positive_clone | F59E12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00035228 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00045884 | |||||||||
| WBPaper00052655 | |||||||||
| WBPaper00052935 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064980 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
