WormBase Tree Display for Gene: WBGene00018987
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| WBGene00018987 | SMap | S_parent | Sequence | F56F10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lgl-1 | Person_evidence | WBPerson3458 | |||||
| WBPerson283 | |||||||||
| Sequence_name | F56F10.4 | ||||||||
| Molecular_name | F56F10.4 | ||||||||
| F56F10.4.1 | |||||||||
| CE45655 | |||||||||
| Other_name | CELE_F56F10.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | lgl-1 | ||||||||
| DB_info | Database | AceView | gene | XB484 | |||||
| WormQTL | gene | WBGene00018987 | |||||||
| WormFlux | gene | WBGene00018987 | |||||||
| NDB | locus_tag | CELE_F56F10.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00018987|UniProtKB=G5EEI1 | |||||||
| family | PTHR10241 | ||||||||
| NCBI | gene | 180435 | |||||||
| RefSeq | protein | NM_075768.6 | |||||||
| TREEFAM | TREEFAM_ID | TF314585 | |||||||
| TrEMBL | UniProtAcc | G5EEI1 | |||||||
| UniProt_GCRP | UniProtAcc | G5EEI1 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 04 Feb 2010 13:59:24 | WBPerson2970 | Name_change | CGC_name | lgl-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lgl | ||||||||
| Allele (97) | |||||||||
| Possibly_affected_by | WBVar02152816 | ||||||||
| WBVar02152820 | |||||||||
| Strain | WBStrain00023580 | ||||||||
| WBStrain00037347 | |||||||||
| WBStrain00054959 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00006594 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | lgl-1 encodes a protein that is related to the Drosophila tumor suppressor Lethal giant larvae (Lgl), a basolateral junction component that regulates cell polarity by controlling localization of proteins to specific regions of the plasma membrane; lgl-1 functions redundantly with par-2 to generate and maintain cell polarity in the early elegans embryo; lgl-1 is involved in the asymmetric partitioning of the PAR (PAR-3/PAR-6/PKC-3) complex most likely by associating with PAR-6 and PKC-3; the association of lgl-1 with the PAR complex is dependent on phosphorylation of lgl-1 by PKC-3; lgl-1 is also required for the proper localization of myosin NMY-2; lgl-1 localizes asymmetrically to the posterior cortex in a PKC-3 dependent manner. | Paper_evidence | WBPaper00032307 | |||||
| WBPaper00036439 | |||||||||
| WBPaper00037740 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 19 Jan 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in establishment of spindle orientation and protein localization. Located in basolateral plasma membrane and cell cortex. Expressed in epithelial cell; intestine; spermathecal cell; and vulval cell. Is an ortholog of human LLGL1 (LLGL scribble cell polarity complex component 1) and LLGL2 (LLGL scribble cell polarity complex component 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F56F10.4 | |||||||
| Corresponding_CDS_history | F56F10.4:wp222 | ||||||||
| Corresponding_transcript | F56F10.4.1 | ||||||||
| Other_sequence | CRC04820_1 | ||||||||
| CR07280 | |||||||||
| Associated_feature | WBsf653672 | ||||||||
| WBsf670090 | |||||||||
| WBsf1003882 | |||||||||
| WBsf1003883 | |||||||||
| WBsf1022182 | |||||||||
| WBsf236972 | |||||||||
| WBsf236973 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr9117 | ||||||||
| Expr9118 | |||||||||
| Expr9154 | |||||||||
| Expr14962 | |||||||||
| Expr1022411 | |||||||||
| Expr1038194 | |||||||||
| Expr1152488 | |||||||||
| Expr2013145 | |||||||||
| Expr2031377 | |||||||||
| Drives_construct | WBCnstr00007645 | ||||||||
| WBCnstr00007646 | |||||||||
| WBCnstr00007647 | |||||||||
| WBCnstr00007648 | |||||||||
| WBCnstr00007649 | |||||||||
| WBCnstr00013751 | |||||||||
| WBCnstr00017184 | |||||||||
| WBCnstr00026146 | |||||||||
| Construct_product | WBCnstr00007645 | ||||||||
| WBCnstr00007646 | |||||||||
| WBCnstr00007647 | |||||||||
| WBCnstr00007648 | |||||||||
| WBCnstr00007649 | |||||||||
| WBCnstr00013731 | |||||||||
| WBCnstr00013751 | |||||||||
| WBCnstr00017184 | |||||||||
| WBCnstr00020200 | |||||||||
| WBCnstr00026146 | |||||||||
| Antibody | WBAntibody00002153 | ||||||||
| WBAntibody00002211 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (111) | |||||||||
| Interaction (184) | |||||||||
| Map_info | Map | X | Position | -19.4653 | Error | 0.003254 | |||
| Positive | Positive_clone | F56F10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
