WormBase Tree Display for Gene: WBGene00006594
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| WBGene00006594 | Evidence | Person_evidence | WBPerson2202 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CGC_data_submission | |||||||||
| SMap | S_parent | Sequence | M01A10 | ||||||
| Identity | Version | 3 | |||||||
| Name | CGC_name | tom-1 | Person_evidence | WBPerson1139 | |||||
| WBPerson520 | |||||||||
| Sequence_name | M01A10.2 | ||||||||
| Molecular_name (21) | |||||||||
| Other_name | tag-23 | CGC_data_submission | |||||||
| tomo-1 | Person_evidence | WBPerson2202 | |||||||
| CELE_M01A10.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | tom-1 | ||||||||
| DB_info | Database | AceView | gene | 1G129 | |||||
| WormQTL | gene | WBGene00006594 | |||||||
| SignaLink | protein | WBGene00006594 | |||||||
| WormFlux | gene | WBGene00006594 | |||||||
| NDB | locus_tag | CELE_M01A10.2 | |||||||
| Panther | gene | CAEEL|EnsemblGenome=WBGene00006594|UniProtKB=A0A0K3ATN9 | |||||||
| family | PTHR10241 | ||||||||
| NCBI | gene | 172209 | |||||||
| RefSeq | protein | NM_059225.5 | |||||||
| NM_001129023.2 | |||||||||
| NM_001313498.3 | |||||||||
| NM_059222.8 | |||||||||
| NM_001313500.3 | |||||||||
| NM_001129022.5 | |||||||||
| NM_001313499.3 | |||||||||
| TrEMBL | UniProtAcc | A0A0K3AWL6 | |||||||
| Q14DX2 | |||||||||
| A8WFN4 | |||||||||
| G5EE26 | |||||||||
| Q49HI3 | |||||||||
| A0A0K3ATN9 | |||||||||
| A0A0K3AR90 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A0K3ATN9 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 16 Feb 2005 14:56:18 | WBPerson2970 | Name_change | CGC_name | tom-1 to tomo-1 | ||||
| 3 | 01 Feb 2006 09:02:02 | WBPerson2970 | Name_change | CGC_name | tom-1 | ||||
| Other_name | tomo-1 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tom | ||||||||
| Allele (178) | |||||||||
| Strain | WBStrain00029062 | ||||||||
| WBStrain00032573 | |||||||||
| WBStrain00035595 | |||||||||
| WBStrain00054856 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (46) | |||||||||
| Ortholog (59) | |||||||||
| Paralog | WBGene00018987 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | tom-1 encodes a tomosyn ortholog that inhibits synaptic vesicle priming; TOM-1 is orthologous to human tomosyn-1 and tomosyn-2, and to Drosophila lethal(2)giant larvae; TOM-1 protein binds RIC-4 (SNAP-25) and UNC-64 (syntaxin) in vitro; tom-1 has two hypomorphic mutant alleles, tom-1(nu468) and tom-1(ok285), which confer aldicarb hypersensitivity, probably from excess cholinergic neurotransmission; tom-1 mutants have reduced brood sizes, mildly defective locomotion, and prolonged responses to neurotransmission due to a defect in presynaptic neurons; tom-1 mutants have normal axonal morphology and numbers of synapses, but abnormally high numbers of neuronal vesicles next to the presynaptic membrane; the tom-1(ok285) mutation suppresses the aldicarb resistance and deficient number of presynaptic membrane-apposed vesicles seen in unc-13(s69) mutants. | Paper_evidence | WBPaper00028364 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 02 Oct 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in several processes, including regulation of neurotransmitter levels; regulation of synaptic vesicle docking; and regulation of synaptic vesicle priming. Located in GABA-ergic synapse; cholinergic synapse; and neuromuscular junction. Is extrinsic component of neuronal dense core vesicle membrane. Part of SNARE complex. Expressed in head neurons; tail neurons; and ventral cord neurons. Is an ortholog of human STXBP5 (syntaxin binding protein 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | M01A10.2a | |||||||
| M01A10.2b | |||||||||
| M01A10.2e | |||||||||
| M01A10.2f | |||||||||
| M01A10.2g | |||||||||
| M01A10.2h | |||||||||
| M01A10.2i | |||||||||
| Corresponding_CDS_history | M01A10.2a:wp102 | ||||||||
| M01A10.2a:wp160 | |||||||||
| M01A10.2b:wp183 | |||||||||
| M01A10.2c:wp102 | |||||||||
| M01A10.2c:wp246 | |||||||||
| M01A10.2d:wp246 | |||||||||
| Corresponding_transcript | M01A10.2a.1 | ||||||||
| M01A10.2b.1 | |||||||||
| M01A10.2e.1 | |||||||||
| M01A10.2f.1 | |||||||||
| M01A10.2g.1 | |||||||||
| M01A10.2h.1 | |||||||||
| M01A10.2i.1 | |||||||||
| Other_sequence (56) | |||||||||
| Associated_feature | WBsf643298 | ||||||||
| WBsf656316 | |||||||||
| WBsf656317 | |||||||||
| WBsf656318 | |||||||||
| WBsf983724 | |||||||||
| WBsf217674 | |||||||||
| WBsf217675 | |||||||||
| WBsf217676 | |||||||||
| WBsf217677 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00050711 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00003989 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034331 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3652 | ||||||||
| Expr4955 | |||||||||
| Expr1021006 | |||||||||
| Expr1032727 | |||||||||
| Expr1154412 | |||||||||
| Expr2017452 | |||||||||
| Expr2035591 | |||||||||
| Drives_construct | WBCnstr00011574 | ||||||||
| WBCnstr00034282 | |||||||||
| Construct_product (11) | |||||||||
| Antibody | WBAntibody00002576 | ||||||||
| Microarray_results (44) | |||||||||
| Expression_cluster (144) | |||||||||
| Interaction (18) | |||||||||
| Map_info | Map | I | Position | 0.113581 | Error | 0.008769 | |||
| Positive | Positive_clone | M01A10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4792 | |||||||
| 4213 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (45) | |||||||||
| Remark | tag-23 has been renamed to tom-1 because this gene is homologous to vertebrate tomosyn | Person_evidence | WBPerson2202 | ||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
