acdh-1 encodes a short-chain acyl-CoA dehydrogenase; ACDH-1 is predicted to be a mitochondrial enzyme that catalyzes the first step of fatty acid beta-oxidation and thus plays a key role in energy production; steady-state acdh-1 mRNA levels are under the control of the MDT-15 mediator complex subunit; in addition, gene expression studies indicate that acdh-1 expression is upregulated in daf-2 mutant animals, but downregulated in fasted animals; loss of acdh-1 activity via RNAi can shorten lifespan.
Predicted to enable acyl-CoA dehydrogenase activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in mitochondrion. Expressed in E lineage cell; hypodermis; and neurons. Is an ortholog of human ACADSB (acyl-CoA dehydrogenase short/branched chain).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.