WormBase Tree Display for Gene: WBGene00016848
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| WBGene00016848 | SMap | S_parent | Sequence | C50F7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | klo-1 | Paper_evidence | WBPaper00037943 | |||||
| Person_evidence | WBPerson1735 | ||||||||
| Sequence_name | C50F7.10 | ||||||||
| Molecular_name | C50F7.10 | ||||||||
| C50F7.10.1 | |||||||||
| CE04248 | |||||||||
| C50F7.10.2 | |||||||||
| Other_name | CELE_C50F7.10 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | klo-1 | ||||||||
| DB_info | Database | AceView | gene | 4I512 | |||||
| WormQTL | gene | WBGene00016848 | |||||||
| WormFlux | gene | WBGene00016848 | |||||||
| NDB | locus_tag | CELE_C50F7.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00016848|UniProtKB=Q18758 | |||||||
| family | PTHR10353 | ||||||||
| NCBI | gene | 177557 | |||||||
| RefSeq | protein | NM_068870.7 | |||||||
| TrEMBL | UniProtAcc | Q18758 | |||||||
| UniProt_GCRP | UniProtAcc | Q18758 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 07 Jan 2011 10:01:10 | WBPerson2970 | Name_change | CGC_name | klo-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | klo | ||||||||
| Allele (28) | |||||||||
| Strain | WBStrain00037138 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00062180 | ||||||||
| 00062181 | |||||||||
| 00122376 | |||||||||
| 00122377 | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00017103 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | klo-1 encodes a homolog of the human beta-glucosidase-like proteins KL (klotho; OMIM:604824, variant in coronary artery disease), KLB (beta-klotho; OMIM:611135), GBA3 (cytosolic beta-glucosidase; OMIM:606619), LCT (lactase-phlorizin hydrolase; OMIM:603202, variant in adult lactose tolerance), and LCTL (lactase-like protein); KLO-1 has 76% identity (364/478 residues) to its paralog encoded by klo-2; perhaps due to genetic redundancy, klo-1 has no obvious function in mass RNAi assays. | Paper_evidence | WBPaper00031047 | |||||
| WBPaper00031048 | |||||||||
| WBPaper00031049 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 Jan 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Expressed in excretory canal; excretory cell; and intestine. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; intracranial embolism; and spondylosis. Is an ortholog of human GBA3 (glucosylceramidase beta 3 (gene/pseudogene)) and LCTL (lactase like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:557 | Homo sapiens | Paper_evidence | WBPaper00037943 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 09 Mar 2021 00:00:00 | ||||||||
| Potential_model | DOID:783 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | |||||
| DOID:4372 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||||
| DOID:2247 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||||
| DOID:784 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||||
| Models_disease_in_annotation | WBDOannot00000890 | ||||||||
| Molecular_info | Corresponding_CDS | C50F7.10 | |||||||
| Corresponding_transcript | C50F7.10.1 | ||||||||
| C50F7.10.2 | |||||||||
| Other_sequence (15) | |||||||||
| Associated_feature | WBsf668048 | ||||||||
| WBsf668049 | |||||||||
| WBsf230317 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr9181 | ||||||||
| Expr1021803 | |||||||||
| Expr1037230 | |||||||||
| Expr1146920 | |||||||||
| Expr2012953 | |||||||||
| Expr2031185 | |||||||||
| Drives_construct (14) | |||||||||
| Construct_product | WBCnstr00008197 | ||||||||
| WBCnstr00008198 | |||||||||
| WBCnstr00008314 | |||||||||
| WBCnstr00008315 | |||||||||
| WBCnstr00008316 | |||||||||
| WBCnstr00008317 | |||||||||
| WBCnstr00008318 | |||||||||
| WBCnstr00027756 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (178) | |||||||||
| Interaction (67) | |||||||||
| Map_info | Map | IV | Position | 3.46595 | Error | 0.001189 | |||
| Positive | Positive_clone | C50F7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
