WormBase Tree Display for Gene: WBGene00016848
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WBGene00016848 | SMap | S_parent | Sequence | C50F7 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | klo-1 | Paper_evidence | WBPaper00037943 | |||
Person_evidence | WBPerson1735 | ||||||
Sequence_name | C50F7.10 | ||||||
Molecular_name | C50F7.10 | ||||||
C50F7.10.1 | |||||||
CE04248 | |||||||
C50F7.10.2 | |||||||
Other_name | CELE_C50F7.10 | Accession_evidence | NDB | BX284604 | |||
Public_name | klo-1 | ||||||
DB_info | Database | AceView | gene | 4I512 | |||
WormQTL | gene | WBGene00016848 | |||||
WormFlux | gene | WBGene00016848 | |||||
NDB | locus_tag | CELE_C50F7.10 | |||||
Panther | gene | CAEEL|WormBase=WBGene00016848|UniProtKB=Q18758 | |||||
family | PTHR10353 | ||||||
NCBI | gene | 177557 | |||||
RefSeq | protein | NM_068870.7 | |||||
TrEMBL | UniProtAcc | Q18758 | |||||
UniProt_GCRP | UniProtAcc | Q18758 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | klo | ||||||
Allele (28) | |||||||
Strain | WBStrain00037138 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00062180 | ||||||
00062181 | |||||||
00122376 | |||||||
00122377 | |||||||
Ortholog (49) | |||||||
Paralog | WBGene00017103 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | klo-1 encodes a homolog of the human beta-glucosidase-like proteins KL (klotho; OMIM:604824, variant in coronary artery disease), KLB (beta-klotho; OMIM:611135), GBA3 (cytosolic beta-glucosidase; OMIM:606619), LCT (lactase-phlorizin hydrolase; OMIM:603202, variant in adult lactose tolerance), and LCTL (lactase-like protein); KLO-1 has 76% identity (364/478 residues) to its paralog encoded by klo-2; perhaps due to genetic redundancy, klo-1 has no obvious function in mass RNAi assays. | Paper_evidence | WBPaper00031047 | |||
WBPaper00031048 | |||||||
WBPaper00031049 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 25 Jan 2011 00:00:00 | ||||||
Automated_description | Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Expressed in excretory canal; excretory cell; and intestine. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; intracranial embolism; and spondylosis. Is an ortholog of human GBA3 (glucosylceramidase beta 3 (gene/pseudogene)) and LCTL (lactase like). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:557 | Homo sapiens | Paper_evidence | WBPaper00037943 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 09 Mar 2021 00:00:00 | ||||||
Potential_model | DOID:783 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | |||
DOID:4372 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||
DOID:2247 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||
DOID:784 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||
DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||
Models_disease_in_annotation | WBDOannot00000890 | ||||||
Molecular_info | Corresponding_CDS | C50F7.10 | |||||
Corresponding_transcript | C50F7.10.1 | ||||||
C50F7.10.2 | |||||||
Other_sequence (15) | |||||||
Associated_feature | WBsf668048 | ||||||
WBsf668049 | |||||||
WBsf230317 | |||||||
Experimental_info | RNAi_result (16) | ||||||
Expr_pattern | Expr9181 | ||||||
Expr1021803 | |||||||
Expr1037230 | |||||||
Expr1146920 | |||||||
Expr2012953 | |||||||
Expr2031185 | |||||||
Drives_construct (14) | |||||||
Construct_product | WBCnstr00008197 | ||||||
WBCnstr00008198 | |||||||
WBCnstr00008314 | |||||||
WBCnstr00008315 | |||||||
WBCnstr00008316 | |||||||
WBCnstr00008317 | |||||||
WBCnstr00008318 | |||||||
WBCnstr00027756 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (178) | |||||||
Interaction (67) | |||||||
Map_info | Map | IV | Position | 3.46595 | Error | 0.001189 | |
Positive | Positive_clone | C50F7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (11) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |