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WormBase Tree Display for Gene: WBGene00016539

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Name Class

WBGene00016539SMapS_parentSequenceC39F7
IdentityVersion6
NameCGC_namemadd-2Person_evidenceWBPerson1820
Sequence_nameC39F7.2
Molecular_nameC39F7.2a
C39F7.2a.1
CE27581
C39F7.2b
CE42345
C39F7.2c
CE51042
C39F7.2b.1
C39F7.2c.1
Other_namerax-1Person_evidenceWBPerson160
trim-9Person_evidenceWBPerson232
WBPerson11460
WBPerson274
Y50D4A.aCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_C39F7.2Accession_evidenceNDBBX284605
Public_namemadd-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:30:57WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
230 Mar 2009 16:33:08WBPerson9133Name_changeCGC_nametrim-9
330 Apr 2010 11:15:49WBPerson2970Name_changeCGC_namemadd-2
Other_nametrim-9
403 Mar 2011 09:42:53WBPerson2970Name_changeCGC_nametrim-9
Other_namemadd-2
524 Mar 2011 10:05:31WBPerson2970EventAcquires_mergeWBGene00044993
Name_changeOther_namerax-1
628 Apr 2014 11:30:35WBPerson2970Name_changeCGC_namemadd-2
Other_nametrim-9
Acquires_mergeWBGene00044993
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmadd
Allele (268)
StrainWBStrain00032432
WBStrain00033425
WBStrain00033426
WBStrain00007190
RNASeq_FPKM (74)
GO_annotation (26)
OrthologWBGene00061080Caenorhabditis remaneiFrom_analysisOMA
TreeFam
WormBase-Compara
WBGene00024366Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00152958Caenorhabditis brenneriFrom_analysisOMA
TreeFam
WormBase-Compara
WBGene00131332Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00191666Caenorhabditis brenneriFrom_analysisTreeFam
WormBase-Compara
WBGene00192189Caenorhabditis brenneriFrom_analysisWormBase-Compara
WBGene00222936Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g919Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g10252Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP21.g2861Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g7207Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g5850Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g8714Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g15103Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP31.g3843Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g13982Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g2147Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g14040Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g27226Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g28368Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g2037Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00424.g10670Caenorhabditis angariaFrom_analysisWormBase-Compara
Cnig_chr_V.g17992Caenorhabditis nigoniFrom_analysisWormBase-Compara
Cnig_chr_V.g17993Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold513.g2595Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_03163.g29271Caenorhabditis sinicaFrom_analysisWormBase-Compara
Csp5_scaffold_04645.g33423Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_12703Caenorhabditis latensFrom_analysisWormBase-Compara
FL83_12704Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_020832Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g05346Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g4316Panagrellus redivivusFrom_analysisWormBase-Compara
Pan_g4317Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_50025400Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrV_pilon.g13195Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00212301Caenorhabditis japonicaFrom_analysisWormBase-Compara
WBGene00216633Caenorhabditis japonicaFrom_analysisWormBase-Compara
WBGene00248892Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00116453Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00264632Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00286619Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0051721Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-030131-8043Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-040426-2936Danio rerioFrom_analysisEnsEMBL-Compara
Panther
SonicParanoid
ZFIN:ZDB-GENE-110825-1Danio rerioFrom_analysisEnsEMBL-Compara
Panther
SonicParanoid
ZFIN:ZDB-GENE-090220-1Danio rerioFrom_analysisEnsEMBL-Compara
Panther
SonicParanoid
ZFIN:ZDB-GENE-060503-466Danio rerioFrom_analysisEnsEMBL-Compara
Panther
SonicParanoid
ZFIN:ZDB-GENE-110411-205Danio rerioFrom_analysisEnsEMBL-Compara
Panther
SonicParanoid
HGNC:7095Homo sapiensFrom_analysisEnsEMBL-Compara
Panther
SonicParanoid
HGNC:7096Homo sapiensFrom_analysisEnsEMBL-Compara
Panther
SonicParanoid
HGNC:16280Homo sapiensFrom_analysisEnsEMBL-Compara
Panther
SonicParanoid
HGNC:19019Homo sapiensFrom_analysisEnsEMBL-Compara
Panther
SonicParanoid
HGNC:16288Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:31859Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:2137354Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:3045323Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:621540Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1560667Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
Paralog (19)
Structured_descriptionConcise_descriptionmadd-2 encodes a protein containing RBCC/TRIM, fibronectin type III, and SPRY domains that is the sole C. elegans member of the C1 subfamily of tripartite motif (TRIM) proteins and is homologous to mammalian TRIM9, TRIM67, and MID1/TRIM18, mutations in which result in Opitz G/BBB syndrome, a congenital malformation disorder affecting ventral midline structures and resulting in mental retardation; in C. elegans, MADD-2 functions cell autonomously as a specificity factor in an UNC-6/Netrin, and UNC-40/DCC-mediated pathway that regulates axon branch formation and attractive axon guidance in multiple neuronal types by potentiating UNC-40 activity; in addition, MADD-2 is required for ventral recruitment of MIG-10/Lamellopodin in the HSNs during outgrowth; MADD-2 also functions cell autonomously in body wall muscle in an UNC-40/DCC and UNC-73/Rho-GEF-mediated pathway to regulate muscle arm extension to ventral midline motor axons; MADD-2 exhibits E3 ubiquitin ligase activity in vitro, physically interacts with both UNC-40 and UNC-73, and may potentiate the in vivo interaction between UNC-40 and UNC-73; a MADD-2::GFP fusion protein is expressed in neurons, hypodermis, and muscle cells; expression is also seen in the anchor cell, the ventral uterine precursor cells and in the ray precursors and descendants in males; in neurons, MADD-2 colocalizes with UNC-40 to the ventral axon branches that require its function; in body wall muscle, MADD-2 localizes to the dense bodies and colocalizes to the muscle arm termini with UNC-40 and UNC-73.Paper_evidenceWBPaper00032907
WBPaper00036484
WBPaper00036485
WBPaper00038152
Curator_confirmedWBPerson1843
Date_last_updated02 Apr 2014 00:00:00
Automated_descriptionEnables protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Involved in cell projection organization; protein ubiquitination; and regulation of protein localization. Located in several cellular components, including cell leading edge; neuronal cell body; and striated muscle dense body. Expressed in several structures, including anchor cell; intestinal cell; muscle cell; neurons; and ray precursor cell. Used to study Opitz GBBB syndrome. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome; anencephaly; and non-syndromic X-linked intellectual disability 101. Is an ortholog of human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:0080697Homo sapiensPaper_evidenceWBPaper00036485
Curator_confirmedWBPerson324
Date_last_updated16 Feb 2021 00:00:00
Potential_modelDOID:0060668Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:16280)
DOID:0112048Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7096)
DOID:0080697Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7095)
Models_disease_assertedWBDOannot00000855
WBDOannot00000856
WBDOannot00000857
Molecular_infoCorresponding_CDSC39F7.2a
C39F7.2b
C39F7.2c
Corresponding_CDS_historyC39F7.2:wp188
Corresponding_transcriptC39F7.2a.1
C39F7.2b.1
C39F7.2c.1
Other_sequence (20)
Associated_feature (21)
Experimental_infoRNAi_resultWBRNAi00011797Inferred_automaticallyRNAi_primary
WBRNAi00065292Inferred_automaticallyRNAi_primary
WBRNAi00076206Inferred_automaticallyRNAi_primary
WBRNAi00042229Inferred_automaticallyRNAi_primary
WBRNAi00011796Inferred_automaticallyRNAi_primary
WBRNAi00020824Inferred_automaticallyRNAi_primary
WBRNAi00080808Inferred_automaticallyRNAi_primary
Expr_pattern (15)
Drives_constructWBCnstr00002505
WBCnstr00007149
WBCnstr00007634
WBCnstr00017575
Construct_product (13)
Microarray_results (26)
Expression_cluster (158)
Interaction (28)
Anatomy_functionWBbtf0412
WBbtf0413
WBbtf0598
Map_infoMapVPosition-19.8476Error0.000552
PositivePositive_cloneC39F7Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataPos_neg_data10757
Pseudo_map_position
Reference (15)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene