WormBase Tree Display for Gene: WBGene00016539

WBGene00016539 SMap: S_parent: Sequence: C39F7
  Identity: Version: 6
    Name: CGC_name: madd-2 Person_evidence: WBPerson1820
      Sequence_name: C39F7.2
      Molecular_name: C39F7.2a
        C39F7.2a.1
        CE27581
        C39F7.2b
        CE42345
        C39F7.2c
        CE51042
        C39F7.2b.1
        C39F7.2c.1
      Other_name: rax-1 Person_evidence: WBPerson160
        trim-9 Person_evidence: WBPerson232
            WBPerson11460
            WBPerson274
        Y50D4A.a Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_C39F7.2 Accession_evidence: NDB BX284605
      Public_name: madd-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 30 Mar 2009 16:33:08 WBPerson9133 Name_change: CGC_name: trim-9
        3 30 Apr 2010 11:15:49 WBPerson2970 Name_change: CGC_name: madd-2
                Other_name: trim-9
        4 03 Mar 2011 09:42:53 WBPerson2970 Name_change: CGC_name: trim-9
                Other_name: madd-2
        5 24 Mar 2011 10:05:31 WBPerson2970 Event: Acquires_merge: WBGene00044993
              Name_change: Other_name: rax-1
        6 28 Apr 2014 11:30:35 WBPerson2970 Name_change: CGC_name: madd-2
                Other_name: trim-9
      Acquires_merge: WBGene00044993
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: madd
    Allele: WBVar00278526
      WBVar00296537
      WBVar00000606
      WBVar02031743
      WBVar00580898
      WBVar02031744
      WBVar00580901
      WBVar00580902
      WBVar00580904
      WBVar00580905
      WBVar00580907
      WBVar00580908
      WBVar01488665
      WBVar00580909
      WBVar02023014
      WBVar01584508
      WBVar01584509
      WBVar01584510
      WBVar01499528
      WBVar01584511
      WBVar01584512
      WBVar01584513
      WBVar01584514
      WBVar01499167
      WBVar01490522
      WBVar02147291
      WBVar00984937
      WBVar00984938
      WBVar00984939
      WBVar00984940
      WBVar00984941
      WBVar00984942
      WBVar00984943
      WBVar00984944
      WBVar01774726
      WBVar00984945
      WBVar00984946
      WBVar01499740
      WBVar01774727
      WBVar00984947
      WBVar01774728
      WBVar00984948
      WBVar01774729
      WBVar01774730
      WBVar00984949
      WBVar01774731
      WBVar00984950
      WBVar01774732
      WBVar00984951
      WBVar01774733
      WBVar00984952
      WBVar01774734
      WBVar00984953
      WBVar01774735
      WBVar00984954
      WBVar00984955
      WBVar01774736
      WBVar01774737
      WBVar02145245
      WBVar00984956
      WBVar00984957
      WBVar00984958
      WBVar00984959
      WBVar00984960
      WBVar00984961
      WBVar00984962
      WBVar00984963
      WBVar00984964
      WBVar00984965
      WBVar00984966
      WBVar00984967
      WBVar00984968
      WBVar00984969
      WBVar00984970
      WBVar00984971
      WBVar00598824
      WBVar00984972
      WBVar00984973
      WBVar01985358
      WBVar00984974
      WBVar01985359
      WBVar00984975
      WBVar01985360
      WBVar00984976
      WBVar00265239
      WBVar00984977
      WBVar00984978
      WBVar00984979
      WBVar01848329
      WBVar00984980
      WBVar00984981
      WBVar00984982
      WBVar01661151
      WBVar00984983
      WBVar01457965
      WBVar01457966
      WBVar00984984
      WBVar01457967
      WBVar00984985
      WBVar01457968
      WBVar00984986
      WBVar00984987
      WBVar01457970
      WBVar00984988
      WBVar01457972
      WBVar01457973
      WBVar00984989
      WBVar00984990
      WBVar01499784
      WBVar00260101
      WBVar01457974
      WBVar00984991
      WBVar01457975
      WBVar01457976
      WBVar00984992
      WBVar01457977
      WBVar00984993
      WBVar00984994
      WBVar00984995
      WBVar00984996
      WBVar00984997
      WBVar00984998
      WBVar01521383
      WBVar00984999
      WBVar01521384
      WBVar00985000
      WBVar01521385
      WBVar00985001
      WBVar01521386
      WBVar00449547
      WBVar01970867
      WBVar01521387
      WBVar00985002
      WBVar00449548
      WBVar00985003
      WBVar01970868
      WBVar01521388
      WBVar00449549
      WBVar00449550
      WBVar01521389
      WBVar01970869
      WBVar00985004
      WBVar00985005
      WBVar00449551
      WBVar01970870
      WBVar00985006
      WBVar01970871
      WBVar02008804
      WBVar00449552
      WBVar00449553
      WBVar01970872
      WBVar00985007
      WBVar01970873
      WBVar00449554
      WBVar00985008
      WBVar00449555
      WBVar01970874
      WBVar00985009
      WBVar00449556
      WBVar00985010
      WBVar01970875
      WBVar00985011
      WBVar00449557
      WBVar00449558
      WBVar00985012
      WBVar00449559
      WBVar00985013
      WBVar00449560
      WBVar00256629
      WBVar00985014
      WBVar00449561
      WBVar00985015
      WBVar00278513
      WBVar00449562
      WBVar00278514
      WBVar00256631
      WBVar00985016
      WBVar00449563
      WBVar00278515
      WBVar00985017
      WBVar00278516
      WBVar00449564
      WBVar00985018
      WBVar00985019
      WBVar00278517
      WBVar00449565
      WBVar00985020
      WBVar00449566
      WBVar00278518
      WBVar00278519
      WBVar00449567
      WBVar00985021
      WBVar00449568
      WBVar00278520
      WBVar00985022
      WBVar00449569
      WBVar00985023
      WBVar00278521
      WBVar00985024
      WBVar00278522
      WBVar00449570
      WBVar00449571
      WBVar00278523
      WBVar00985025
      WBVar00449572
      WBVar01737635
      WBVar00278524
      WBVar00278525
      WBVar00449573
      WBVar00449574
      WBVar00449575
      WBVar01924640
      WBVar00449576
      WBVar01924641
      WBVar00449577
      WBVar02051822
      WBVar00449578
      WBVar00449579
      WBVar02051823
      WBVar02051824
      WBVar00449580
      WBVar00449581
      WBVar02051825
      WBVar00449582
      WBVar02051826
      WBVar00449583
      WBVar00000610
      WBVar00449584
      WBVar00449585
      WBVar00202601
      WBVar00449586
      WBVar00202602
      WBVar00449587
      WBVar00202603
      WBVar00449588
      WBVar00202604
      WBVar00449589
      WBVar00449590
      WBVar00202605
      WBVar00202606
      WBVar00449591
      WBVar02135684
      WBVar00202607
      WBVar00449592
      WBVar02135685
      WBVar00449593
      WBVar00202608
      WBVar00202609
      WBVar02135686
      WBVar00316761
      WBVar00316762
      WBVar01483472
      WBVar00260174
      WBVar00093390
      WBVar01499496
      WBVar01833775
      WBVar01833776
      WBVar01833777
      WBVar01833778
      WBVar01833779
      WBVar01833780
      WBVar01833781
      WBVar01674162
      WBVar02031740
      WBVar02031741
      WBVar01500066
      WBVar02031742
      WBVar00580897
    Strain: WBStrain00032432
      WBStrain00033425
      WBStrain00033426
      WBStrain00007190
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog (58)
    Paralog (19)
    Structured_description: Concise_description: madd-2 encodes a protein containing RBCC/TRIM, fibronectin type III, and SPRY domains that is the sole C. elegans member of the C1 subfamily of tripartite motif (TRIM) proteins and is homologous to mammalian TRIM9, TRIM67, and MID1/TRIM18, mutations in which result in Opitz G/BBB syndrome, a congenital malformation disorder affecting ventral midline structures and resulting in mental retardation; in C. elegans, MADD-2 functions cell autonomously as a specificity factor in an UNC-6/Netrin, and UNC-40/DCC-mediated pathway that regulates axon branch formation and attractive axon guidance in multiple neuronal types by potentiating UNC-40 activity; in addition, MADD-2 is required for ventral recruitment of MIG-10/Lamellopodin in the HSNs during outgrowth; MADD-2 also functions cell autonomously in body wall muscle in an UNC-40/DCC and UNC-73/Rho-GEF-mediated pathway to regulate muscle arm extension to ventral midline motor axons; MADD-2 exhibits E3 ubiquitin ligase activity in vitro, physically interacts with both UNC-40 and UNC-73, and may potentiate the in vivo interaction between UNC-40 and UNC-73; a MADD-2::GFP fusion protein is expressed in neurons, hypodermis, and muscle cells; expression is also seen in the anchor cell, the ventral uterine precursor cells and in the ray precursors and descendants in males; in neurons, MADD-2 colocalizes with UNC-40 to the ventral axon branches that require its function; in body wall muscle, MADD-2 localizes to the dense bodies and colocalizes to the muscle arm termini with UNC-40 and UNC-73. Paper_evidence: WBPaper00032907
            WBPaper00036484
            WBPaper00036485
            WBPaper00038152
          Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Apr 2014 00:00:00
      Automated_description: Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Involved in cell projection organization; protein ubiquitination; and regulation of protein localization. Located in several cellular components, including cell leading edge; neuronal cell body; and striated muscle dense body. Expressed in several structures, including anchor cell; intestinal cell; muscle cell; neurons; and ray precursor cell. Used to study Opitz GBBB syndrome. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome; anencephaly; and non-syndromic X-linked intellectual disability 101. Is an ortholog of human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0080697 Homo sapiens Paper_evidence: WBPaper00036485
          Curator_confirmed: WBPerson324
          Date_last_updated: 16 Feb 2021 00:00:00
    Potential_model: DOID:0060668 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16280)
      DOID:0112048 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7096)
      DOID:0080697 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7095)
  Models_disease_asserted: WBDOannot00000855
    WBDOannot00000856
    WBDOannot00000857
  Molecular_info: Corresponding_CDS: C39F7.2a
      C39F7.2b
      C39F7.2c
    Corresponding_CDS_history: C39F7.2:wp188
    Corresponding_transcript: C39F7.2a.1
      C39F7.2b.1
      C39F7.2c.1
    Other_sequence (20)
    Associated_feature (21)
  Experimental_info: RNAi_result: WBRNAi00011797 Inferred_automatically: RNAi_primary
      WBRNAi00065292 Inferred_automatically: RNAi_primary
      WBRNAi00076206 Inferred_automatically: RNAi_primary
      WBRNAi00042229 Inferred_automatically: RNAi_primary
      WBRNAi00011796 Inferred_automatically: RNAi_primary
      WBRNAi00020824 Inferred_automatically: RNAi_primary
      WBRNAi00080808 Inferred_automatically: RNAi_primary
    Expr_pattern (15)
    Drives_construct: WBCnstr00002505
      WBCnstr00007149
      WBCnstr00007634
      WBCnstr00017575
    Construct_product (13)
    Microarray_results (26)
    Expression_cluster (158)
    Interaction (28)
    Anatomy_function: WBbtf0412
      WBbtf0413
      WBbtf0598
  Map_info: Map: V Position: -19.8476 Error: 0.000552
    Positive: Positive_clone: C39F7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Pos_neg_data: 10757
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene