WormBase Tree Display for Gene: WBGene00016197
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| WBGene00016197 | SMap | S_parent | Sequence | C28H8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | pxl-1 | Person_evidence | WBPerson4000 | |||||
| WBPerson427 | |||||||||
| Sequence_name | C28H8.6 | ||||||||
| Molecular_name | C28H8.6a | ||||||||
| C28H8.6a.1 | |||||||||
| CE41530 | |||||||||
| C28H8.6b | |||||||||
| CE37096 | |||||||||
| C28H8.6c | |||||||||
| CE41531 | |||||||||
| C28H8.6b.1 | |||||||||
| C28H8.6c.1 | |||||||||
| Other_name | tag-327 | ||||||||
| CELE_C28H8.6 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | pxl-1 | ||||||||
| DB_info | Database | AceView | gene | 3G980 | |||||
| WormQTL | gene | WBGene00016197 | |||||||
| WormFlux | gene | WBGene00016197 | |||||||
| NDB | locus_tag | CELE_C28H8.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00016197|UniProtKB=Q09476 | |||||||
| family | PTHR24216 | ||||||||
| NCBI | gene | 175831 | |||||||
| RefSeq | protein | NM_001026014.5 | |||||||
| NM_001129205.4 | |||||||||
| NM_001026015.3 | |||||||||
| SwissProt | UniProtAcc | Q09476 | |||||||
| UniProt_GCRP | UniProtAcc | Q09476 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 22 Apr 2005 11:55:18 | WBPerson2970 | Name_change | CGC_name | tag-327 | ||||
| 3 | 06 Sep 2007 16:55:39 | WBPerson1849 | Event | Acquires_merge | WBGene00044601 | ||||
| 4 | 10 Sep 2007 09:52:01 | WBPerson2970 | Name_change | CGC_name | pxl-1 | ||||
| Acquires_merge | WBGene00044601 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pxl | ||||||||
| Allele (70) | |||||||||
| Strain | WBStrain00036247 | ||||||||
| WBStrain00006068 | |||||||||
| WBStrain00006125 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00004030 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WBGene00007740 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00012379 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022030 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00016389 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018000 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | pxl-1 encodes proteins containing N-terminal LD motifs and C-terminal LIM domains that is the C. elegans ortholog of vertebrate paxillin; pxl-1 is required for organized myofilament structure in the pharynx and pharyngeal muscle contraction, and hence feeding and viability past the first larval stage; PXL-1 is expressed in body wall and pharyngeal muscle, as well as pharyngeal epithelial cells; PXL-1 localizes to sites of actin attachment, namely dense bodies, adhesion plaques, and M-lines in body wall muscle, and podosome-like structures in pharyngeal muscle; pxl-1 expression in pharyngeal muscle and marginal cells is sufficient to rescue the pharyngeal muscle defects and lethality of a pxl-1 mutant; PXL-1 physically interacts with muscle proteins DEB-1, UIG-1, LIM-8, UNC-96, UNC-95, and HUM-6. | Paper_evidence | WBPaper00038481 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables vinculin binding activity. Involved in muscle structure development; nematode larval development; and pharyngeal pumping. Located in adherens junction; contractile fiber; and podosome. Expressed in pharyngeal muscle cell and pharynx. Is an ortholog of human LPXN (leupaxin) and PXN (paxillin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C28H8.6a | |||||||
| C28H8.6b | |||||||||
| C28H8.6c | |||||||||
| Corresponding_CDS_history | C28H8.6:wp127 | ||||||||
| C28H8.6a:wp181 | |||||||||
| C28H8.6b:wp181 | |||||||||
| Corresponding_transcript | C28H8.6a.1 | ||||||||
| C28H8.6b.1 | |||||||||
| C28H8.6c.1 | |||||||||
| Other_sequence (83) | |||||||||
| Associated_feature (13) | |||||||||
| Transcription_factor | WBTranscriptionFactor000391 | ||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr9318 | ||||||||
| Expr9319 | |||||||||
| Expr9320 | |||||||||
| Expr1019414 | |||||||||
| Expr1036932 | |||||||||
| Expr1145462 | |||||||||
| Expr2015199 | |||||||||
| Expr2033433 | |||||||||
| Drives_construct | WBCnstr00008714 | ||||||||
| WBCnstr00008716 | |||||||||
| WBCnstr00013898 | |||||||||
| WBCnstr00013899 | |||||||||
| WBCnstr00028253 | |||||||||
| Construct_product | WBCnstr00008713 | ||||||||
| WBCnstr00008714 | |||||||||
| WBCnstr00008716 | |||||||||
| WBCnstr00013898 | |||||||||
| WBCnstr00013899 | |||||||||
| WBCnstr00028253 | |||||||||
| Antibody | WBAntibody00002229 | ||||||||
| Microarray_results (39) | |||||||||
| Expression_cluster (115) | |||||||||
| Interaction (76) | |||||||||
| Map_info | Map | III | Position | -1.43653 | |||||
| Positive | Positive_clone | C28H8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5146 | |||||||
| 4769 | |||||||||
| 4963 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00028063 | ||||||||
| WBPaper00030707 | |||||||||
| WBPaper00033491 | |||||||||
| WBPaper00036199 | |||||||||
| WBPaper00038481 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
