WormBase Tree Display for Gene: WBGene00016197
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WBGene00016197 | SMap | S_parent | Sequence | C28H8 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | pxl | |||||
Allele (70) | ||||||
Strain | WBStrain00036247 | |||||
WBStrain00006068 | ||||||
WBStrain00006125 | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (23) | ||||||
Ortholog (39) | ||||||
Paralog | WBGene00004030 | Caenorhabditis elegans | From_analysis | TreeFam | ||
WBGene00007740 | Caenorhabditis elegans | From_analysis | Panther | |||
WBGene00012379 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | ||||||
WBGene00022030 | Caenorhabditis elegans | From_analysis | Panther | |||
WBGene00016389 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | ||||||
WBGene00018000 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | ||||||
Structured_description | Concise_description | pxl-1 encodes proteins containing N-terminal LD motifs and C-terminal LIM domains that is the C. elegans ortholog of vertebrate paxillin; pxl-1 is required for organized myofilament structure in the pharynx and pharyngeal muscle contraction, and hence feeding and viability past the first larval stage; PXL-1 is expressed in body wall and pharyngeal muscle, as well as pharyngeal epithelial cells; PXL-1 localizes to sites of actin attachment, namely dense bodies, adhesion plaques, and M-lines in body wall muscle, and podosome-like structures in pharyngeal muscle; pxl-1 expression in pharyngeal muscle and marginal cells is sufficient to rescue the pharyngeal muscle defects and lethality of a pxl-1 mutant; PXL-1 physically interacts with muscle proteins DEB-1, UIG-1, LIM-8, UNC-96, UNC-95, and HUM-6. | Paper_evidence | WBPaper00038481 | ||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 10 Aug 2011 00:00:00 | |||||
Automated_description | Enables vinculin binding activity. Involved in muscle structure development; nematode larval development; and pharyngeal pumping. Located in adherens junction; contractile fiber; and podosome. Expressed in pharyngeal muscle cell and pharynx. Is an ortholog of human LPXN (leupaxin) and PXN (paxillin). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | C28H8.6a | ||||
C28H8.6b | ||||||
C28H8.6c | ||||||
Corresponding_CDS_history | C28H8.6:wp127 | |||||
C28H8.6a:wp181 | ||||||
C28H8.6b:wp181 | ||||||
Corresponding_transcript | C28H8.6a.1 | |||||
C28H8.6b.1 | ||||||
C28H8.6c.1 | ||||||
Other_sequence (83) | ||||||
Associated_feature (13) | ||||||
Transcription_factor | WBTranscriptionFactor000391 | |||||
Experimental_info | RNAi_result (15) | |||||
Expr_pattern | Expr9318 | |||||
Expr9319 | ||||||
Expr9320 | ||||||
Expr1019414 | ||||||
Expr1036932 | ||||||
Expr1145462 | ||||||
Expr2015199 | ||||||
Expr2033433 | ||||||
Drives_construct | WBCnstr00008714 | |||||
WBCnstr00008716 | ||||||
WBCnstr00013898 | ||||||
WBCnstr00013899 | ||||||
WBCnstr00028253 | ||||||
Construct_product | WBCnstr00008713 | |||||
WBCnstr00008714 | ||||||
WBCnstr00008716 | ||||||
WBCnstr00013898 | ||||||
WBCnstr00013899 | ||||||
WBCnstr00028253 | ||||||
Antibody | WBAntibody00002229 | |||||
Microarray_results (39) | ||||||
Expression_cluster (115) | ||||||
Interaction (76) | ||||||
Map_info | Map | III | Position | -1.43653 | ||
Positive | Positive_clone | C28H8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||
Mapping_data | Multi_point | 5146 | ||||
4769 | ||||||
4963 | ||||||
Pseudo_map_position | ||||||
Reference | WBPaper00028063 | |||||
WBPaper00030707 | ||||||
WBPaper00033491 | ||||||
WBPaper00036199 | ||||||
WBPaper00038481 | ||||||
WBPaper00038491 | ||||||
WBPaper00055090 | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |