WormBase Tree Display for Gene: WBGene00016185

WBGene00016185 SMap: S_parent: Sequence: C28F5
  Identity: Version: 2
    Name: Sequence_name: C28F5.4
      Molecular_name: C28F5.4
      Other_name: CELE_C28F5.4 Accession_evidence: NDB BX284602
      Public_name: C28F5.4
    DB_info: Database: AceView gene 2H808
        WormQTL gene WBGene00016185
        SignaLink protein WBGene00016185
        WormFlux gene WBGene00016185
        NDB locus_tag CELE_C28F5.4
        NCBI gene 182987
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 21 Oct 2019 15:27:04 WBPerson4025 Event: Changed_class: CDS Pseudogene
    Status: Live
  Gene_info: Biotype: SO:0000336
    Allele (59)
    RNASeq_FPKM (74)
    Ortholog: WBGene00030925 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00155264 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00127059 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00058877 Caenorhabditis remanei From_analysis: TreeFam
      SGD:S000004381 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0001247 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-070410-85 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:5381 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      MGI:96412 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2861 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00013492 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
      WBGene00015359 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
      WBGene00015360 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
      WBGene00018426 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
    Structured_description: Automated_description: Enriched in male based on RNA-seq studies. Is affected by several genes including eat-2; sir-2.1; and npr-1 based on tiling array; microarray; and RNA-seq studies. Is affected by four chemicals including antimycin; Doxycycline; and paraquat based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in Alzheimer's disease; diabetic encephalopathy; and type 2 diabetes mellitus. Human IDE enables several functions, including insulin binding activity; ion binding activity; and protein homodimerization activity. Is an ortholog of human IDE (insulin degrading enzyme). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5381)
      DOID:0050850 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5381)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5381)
  Molecular_info: Corresponding_CDS_history: C28F5.4:wp156
      C28F5.4:wp274
    Corresponding_pseudogene: C28F5.4
    Other_sequence: BMC02508_1
  Experimental_info: Expr_pattern: Expr1019568
      Expr1145448
    Drives_construct: WBCnstr00028262
    Construct_product: WBCnstr00028262
    Microarray_results (18)
    Expression_cluster (53)
    Interaction (28)
  Map_info: Positive: Positive_clone: C28F5 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: II 0.503578
  Reference: WBPaper00038491
    WBPaper00049886
    WBPaper00055090
    WBPaper00063976
  Method: Gene