WormBase Tree Display for Gene: WBGene00015735
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| WBGene00015735 | SMap | S_parent | Sequence | C13B9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | pdfr-1 | Paper_evidence | WBPaper00031656 | |||||
| Person_evidence | WBPerson3516 | ||||||||
| WBPerson3480 | |||||||||
| Sequence_name | C13B9.4 | ||||||||
| Molecular_name (23) | |||||||||
| Other_name | seb-1 | Person_evidence | WBPerson3006 | ||||||
| WBPerson1263 | |||||||||
| CELE_C13B9.4 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | pdfr-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 18 Apr 2008 13:26:44 | WBPerson2970 | Name_change | CGC_name | pdfr-1 | ||||
| 3 | 29 Aug 2012 16:49:31 | WBPerson2970 | Name_change | Other_name | seb-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pdfr | ||||||||
| Allele (246) | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00007664 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00014035 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00002251 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00002252 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009304 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017947 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017948 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | pdfr-1 encodes, by alternative splicing, three isoforms of a G-protein-coupled receptor (GPCR) required for normal locomotion; PDFR-1 is orthologous to Drosophila pigment dispersing factor (PDF) receptors, and to human CALCR (OMIM:114131, associated with susceptibility to osteoporesis); pdfr-1 is expressed in all body wall muscles and many head and tail neurons; the C. elegans neuropeptides PDF-1a, PDF-1b, or PDF-2 (orthologous to Drosophila PDF) activated PDFR-1 receptors with dose-dependent nanomolar potency; in vivo, excess PDF-2 induces a movement phenotype like that seen in a pdf-1 null mutant, indicating that PDF-1a/b and PDF-2 exert opposite effects on PDFR-1. | Paper_evidence | WBPaper00012979 | |||||
| WBPaper00028902 | |||||||||
| WBPaper00031656 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 14 Jul 2008 00:00:00 | ||||||||
| Automated_description | Enables calcitonin family receptor activity. Involved in several processes, including locomotory behavior; signal transduction; and sleep. Located in plasma membrane. Expressed in several structures, including I1 neuron; RMEV; ganglia; mechanosensory neurons; and vulD. Human ortholog(s) of this gene implicated in bone disease (multiple); hereditary lymphedema; and primary failure of tooth eruption. Is an ortholog of human CALCR (calcitonin receptor); CALCRL (calcitonin receptor like receptor); and PTH1R (parathyroid hormone 1 receptor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080020 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) | ||||
| DOID:0050580 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16709) | ||||||
| DOID:0060387 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) | ||||||
| DOID:2256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) | ||||||
| DOID:0111341 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) | ||||||
| DOID:11476 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1440) | ||||||
| DOID:0111732 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) | ||||||
| Molecular_info | Corresponding_CDS | C13B9.4a | |||||||
| C13B9.4b | |||||||||
| C13B9.4c | |||||||||
| C13B9.4d | |||||||||
| C13B9.4e | |||||||||
| Corresponding_CDS_history | C13B9.4:wp127 | ||||||||
| Corresponding_transcript (13) | |||||||||
| Other_sequence (25) | |||||||||
| Associated_feature (24) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00010677 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00005367 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027171 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040427 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00024543 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00024544 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028838 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00002179 | ||||||||
| WBCnstr00002180 | |||||||||
| WBCnstr00004248 | |||||||||
| WBCnstr00004988 | |||||||||
| WBCnstr00015834 | |||||||||
| WBCnstr00015836 | |||||||||
| WBCnstr00019100 | |||||||||
| WBCnstr00021690 | |||||||||
| WBCnstr00021702 | |||||||||
| WBCnstr00028610 | |||||||||
| Construct_product (12) | |||||||||
| Antibody | WBAntibody00001399 | ||||||||
| Microarray_results (36) | |||||||||
| Expression_cluster (224) | |||||||||
| Interaction (12) | |||||||||
| Map_info | Map | III | Position | -1.02511 | Error | 0.00506 | |||
| Positive | Positive_clone | C13B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00010230 | ||||||||
| WBPaper00012979 | |||||||||
| WBPaper00018302 | |||||||||
| WBPaper00019605 | |||||||||
| WBPaper00028902 | |||||||||
| WBPaper00031656 | |||||||||
| WBPaper00034125 | |||||||||
| WBPaper00035341 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00039422 | |||||||||
| WBPaper00041096 | |||||||||
| WBPaper00041718 | |||||||||
| WBPaper00042479 | |||||||||
| WBPaper00043197 | |||||||||
| WBPaper00043343 | |||||||||
| WBPaper00043454 | |||||||||
| WBPaper00044094 | |||||||||
| WBPaper00047014 | |||||||||
| WBPaper00047452 | |||||||||
| WBPaper00047602 | |||||||||
| WBPaper00047901 | |||||||||
| WBPaper00051653 | |||||||||
| WBPaper00054889 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00055514 | |||||||||
| WBPaper00057426 | |||||||||
| WBPaper00061844 | |||||||||
| WBPaper00062055 | |||||||||
| WBPaper00062132 | |||||||||
| WBPaper00062771 | |||||||||
| WBPaper00063630 | |||||||||
| WBPaper00063685 | |||||||||
| WBPaper00063827 | |||||||||
| WBPaper00063837 | |||||||||
| WBPaper00063859 | |||||||||
| WBPaper00065946 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
