WormBase Tree Display for Gene: WBGene00015648
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| WBGene00015648 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | orai-1 | Person_evidence | WBPerson1851 | |||||
| Sequence_name | C09F5.2 | ||||||||
| Molecular_name | C09F5.2a | ||||||||
| C09F5.2a.1 | |||||||||
| CE42990 | |||||||||
| C09F5.2b | |||||||||
| CE01774 | |||||||||
| C09F5.2a.2 | |||||||||
| C09F5.2b.1 | |||||||||
| Other_name | CELE_C09F5.2 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | orai-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 18 Jul 2006 14:35:12 | WBPerson2970 | Name_change | CGC_name | orai-1 | ||||
| 3 | 03 Nov 2008 13:42:45 | WBPerson1867 | Event | Acquires_merge | WBGene00021065 | ||||
| Acquires_merge | WBGene00021065 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | orai | ||||||||
| Allele (179) | |||||||||
| Strain | WBStrain00002066 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Contained_in_operon | CEOP3859 | ||||||||
| Ortholog (46) | |||||||||
| Structured_description | Concise_description | orai-1 encodes a calcium release activated calcium (CRAC) channel orthologous to the vertebrate ORAI family of proteins; ORAI-1 activity is required for normal levels of fertility and for store-operated calcium channel (SOCC) activity in intestinal epithelial cells; co-expression of ORAI-1 and STIM-1 in HEK293 cells results in large inwardly rectifying cation currents activated by endoplasmic reticulum calcium depletion; ORAI-1 is expressed in the gonad and in the intestine; in the intestine, ORAI-1 appears to localize to the apical and basal plasma membrane; in the spermatheca, ORAI-1 expression is consistent with localization to the basal plasma membrane. | Paper_evidence | WBPaper00028994 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 21 May 2014 00:00:00 | ||||||||
| Automated_description | Enables store-operated calcium channel activity. Involved in ovulation and store-operated calcium entry. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated calcium channel complex. Expressed in gonadal sheath cell; head; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Is an ortholog of human ORAI2 (ORAI calcium release-activated calcium modulator 2) and ORAI3 (ORAI calcium release-activated calcium modulator 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25896) | ||||
| DOID:0111976 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25896) | ||||||
| Molecular_info | Corresponding_CDS | C09F5.2a | |||||||
| C09F5.2b | |||||||||
| Corresponding_CDS_history | C09F5.2:wp194 | ||||||||
| Corresponding_transcript | C09F5.2a.1 | ||||||||
| C09F5.2a.2 | |||||||||
| C09F5.2b.1 | |||||||||
| Other_sequence (41) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00090597 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00028729 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010525 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085731 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001126 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054897 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040207 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006596 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram2030 | ||||||||
| Expr4783 | |||||||||
| Expr5220 | |||||||||
| Expr5221 | |||||||||
| Expr1013330 | |||||||||
| Expr1036702 | |||||||||
| Expr1144278 | |||||||||
| Expr2014632 | |||||||||
| Expr2032865 | |||||||||
| Drives_construct | WBCnstr00002229 | ||||||||
| WBCnstr00004260 | |||||||||
| WBCnstr00008590 | |||||||||
| WBCnstr00012242 | |||||||||
| WBCnstr00028687 | |||||||||
| Construct_product | WBCnstr00008590 | ||||||||
| WBCnstr00012242 | |||||||||
| WBCnstr00028687 | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction | WBInteraction000556188 | ||||||||
| WBInteraction000556189 | |||||||||
| WBInteraction000556190 | |||||||||
| WBInteraction000556191 | |||||||||
| Map_info | Map | III | Position | -26.3293 | Error | 0.015704 | |||
| Positive | Positive_clone | C09F5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00028994 | ||||||||
| WBPaper00030263 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00047380 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
