WormBase Tree Display for Gene: WBGene00015400
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| WBGene00015400 | SMap | S_parent | Sequence | C03G6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cyp-35A2 | |||||||
| Sequence_name | C03G6.15 | ||||||||
| Molecular_name | C03G6.15 | ||||||||
| C03G6.15.1 | |||||||||
| CE35217 | |||||||||
| Other_name | CELE_C03G6.15 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | cyp-35A2 | ||||||||
| DB_info | Database | AceView | gene | 5H840 | |||||
| WormQTL | gene | WBGene00015400 | |||||||
| WormFlux | gene | WBGene00015400 | |||||||
| NDB | locus_tag | CELE_C03G6.15 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00015400|UniProtKB=O02628 | |||||||
| family | PTHR24300 | ||||||||
| NCBI | gene | 182177 | |||||||
| RefSeq | protein | NM_072479.7 | |||||||
| TrEMBL | UniProtAcc | O02628 | |||||||
| UniProt_GCRP | UniProtAcc | O02628 | |||||||
| OMIM | gene | 601130 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | cyp-35A2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyp | ||||||||
| Allele (33) | |||||||||
| Strain | WBStrain00036000 | ||||||||
| WBStrain00036030 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (177) | |||||||||
| Paralog (44) | |||||||||
| Structured_description | Concise_description | cyp-35A2 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; RT-PCR experiments indicate that cyp-35A2 mRNA is upregulated in response to treatment with xenobiotics, such as PCBs (polychlorinated biphenyls) or PAHs (polycyclic aromatic hydrocarbons); loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; in addition, cyp-35A(RNAi) also results in a reduction of fat content; cyp-35A2 reporter gene fusions are strongly expressed in the intestine following treatment with xenobiotics. | Paper_evidence | WBPaper00004966 | |||||
| WBPaper00005655 | |||||||||
| WBPaper00025207 | |||||||||
| WBPaper00031939 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Feb 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2A13 (cytochrome P450 family 2 subfamily A member 13); CYP2A6 (cytochrome P450 family 2 subfamily A member 6); and CYP2A7 (cytochrome P450 family 2 subfamily A member 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (57) | ||||||||
| Molecular_info | Corresponding_CDS | C03G6.15 | |||||||
| Corresponding_CDS_history | C03G6.15:wp106 | ||||||||
| Corresponding_transcript | C03G6.15.1 | ||||||||
| Other_sequence | ES740345.1 | ||||||||
| Tcol_isotig20275 | |||||||||
| Associated_feature | WBsf652771 | ||||||||
| WBsf669117 | |||||||||
| WBsf233940 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00039543 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00116295 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092682 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010068 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114818 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00078475 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106221 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028398 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1683 | ||||||||
| Expr8189 | |||||||||
| Expr11595 | |||||||||
| Expr1029051 | |||||||||
| Expr1036590 | |||||||||
| Expr1143647 | |||||||||
| Expr2010735 | |||||||||
| Expr2028972 | |||||||||
| Drives_construct | WBCnstr00004995 | ||||||||
| WBCnstr00010373 | |||||||||
| WBCnstr00019076 | |||||||||
| WBCnstr00028873 | |||||||||
| Construct_product | WBCnstr00019076 | ||||||||
| WBCnstr00028873 | |||||||||
| Microarray_results (14) | |||||||||
| Expression_cluster (292) | |||||||||
| Interaction (49) | |||||||||
| Map_info | Map | V | Position | 0.715015 | Error | 0.002421 | |||
| Positive | Positive_clone | C03G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5576 | |||||||
| Pseudo_map_position | |||||||||
| Reference (27) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
