WormBase Tree Display for Gene: WBGene00013352
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| WBGene00013352 | SMap | S_parent | Sequence | Y59A8B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lon-8 | Paper_evidence | WBPaper00029198 | |||||
| Person_evidence | WBPerson219 | ||||||||
| Sequence_name | Y59A8B.20 | ||||||||
| Molecular_name | Y59A8B.20 | ||||||||
| Y59A8B.20.1 | |||||||||
| CE41522 | |||||||||
| Other_name | Y59A8B.j | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y59A8B.20 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | lon-8 | ||||||||
| DB_info | Database | AceView | gene | 5S476 | |||||
| WormQTL | gene | WBGene00013352 | |||||||
| WormFlux | gene | WBGene00013352 | |||||||
| NDB | locus_tag | CELE_Y59A8B.20 | |||||||
| NCBI | gene | 190397 | |||||||
| RefSeq | protein | NM_075119.5 | |||||||
| SwissProt | UniProtAcc | G5EGH7 | |||||||
| TREEFAM | TREEFAM_ID | TF353880 | |||||||
| UniProt_GCRP | UniProtAcc | G5EGH7 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 03 Apr 2007 10:48:52 | WBPerson2970 | Name_change | CGC_name | lon-8 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lon | ||||||||
| Allele (210) | |||||||||
| Strain | WBStrain00023616 | ||||||||
| WBStrain00023617 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00020246 | ||||||||
| 00020247 | |||||||||
| 00020248 | |||||||||
| 00020249 | |||||||||
| 00020250 | |||||||||
| Ortholog (28) | |||||||||
| Structured_description | Concise_description | lon-8 encodes a secreted protein, conserved among nematodes, thatinhibits body elongation during larval and early adult growth, probablyby limiting cell size rather than nuclear ploidy or cell number; LON-8is also required for normal ray morphology in the male tail, but not forsuperficially normal male mating, suggesting a role in cuticleretraction; LON-8 is strongly expressed in the hypodermal syncytia hyp4and hyp7, and appears to be secreted from them in vivo; in males, LON-8is also expressed in male tail hypodermal nuclei (V6.pppaa, T.aa, R6.p,T.apapa, R7.p, R8.p and R9.p); LON-8 has no obvious non-nematodehomologs; LON-8 activity is genetically independent of DBL-1/TGF-betasignalling; newly hatched lon-8(hu187) larvae are normal in length, butthen outgrow wild-type larvae at a rate similar to that of lon-1(e185)larvae until 96 hours post-hatching, after which lon-8(hu187) growth wasnormal; lon-8(hu187) mutants have normal levels of hypodermalendoreduplication and of seam cell fusion; lon-8(hu187) is suppressed bymutations of dpy-11 or dpy-18; conversely, lon-8(hu187) does notsuppress dbl-1(nk3) or sma-6(e1482), and lon-8 transcripts are notaffected by dbl-1(nk3) or sma-6(e1482) mutations. | Paper_evidence | WBPaper00006395 | |||||
| WBPaper00029198 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 08 May 2007 00:00:00 | ||||||||
| Automated_description | Involved in nematode male tail tip morphogenesis and regulation of growth. Predicted to be located in extracellular space. Expressed in hyp4; hyp7 syncytium; and intestine. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y59A8B.20 | |||||||
| Corresponding_CDS_history | Y59A8B.20:wp125 | ||||||||
| Y59A8B.20:wp180 | |||||||||
| Corresponding_transcript | Y59A8B.20.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf669836 | ||||||||
| WBsf718465 | |||||||||
| WBsf1002797 | |||||||||
| WBsf1002798 | |||||||||
| WBsf1002799 | |||||||||
| WBsf1002800 | |||||||||
| WBsf1021381 | |||||||||
| WBsf1021382 | |||||||||
| WBsf1021383 | |||||||||
| WBsf1021384 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00037626 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00057750 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065819 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027541 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026882 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021164 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4607 | ||||||||
| Expr4608 | |||||||||
| Expr1024390 | |||||||||
| Expr1035963 | |||||||||
| Expr1161172 | |||||||||
| Expr2013246 | |||||||||
| Expr2031477 | |||||||||
| Drives_construct | WBCnstr00012113 | ||||||||
| WBCnstr00012114 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (245) | |||||||||
| Interaction | WBInteraction000552655 | ||||||||
| WBInteraction000561993 | |||||||||
| WBInteraction000567986 | |||||||||
| Map_info | Map | V | Position | 13.4085 | Error | 0.008433 | |||
| Positive | Positive_clone | Y59A8B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00029198 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
