WormBase Tree Display for Gene: WBGene00013352
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WBGene00013352 | SMap | S_parent | Sequence | Y59A8B | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | lon-8 | Paper_evidence | WBPaper00029198 | |||
Person_evidence | WBPerson219 | ||||||
Sequence_name | Y59A8B.20 | ||||||
Molecular_name | Y59A8B.20 | ||||||
Y59A8B.20.1 | |||||||
CE41522 | |||||||
Other_name | Y59A8B.j | Curator_confirmed | WBPerson1983 | ||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||
CELE_Y59A8B.20 | Accession_evidence | NDB | BX284605 | ||||
Public_name | lon-8 | ||||||
DB_info | Database | AceView | gene | 5S476 | |||
WormQTL | gene | WBGene00013352 | |||||
WormFlux | gene | WBGene00013352 | |||||
NDB | locus_tag | CELE_Y59A8B.20 | |||||
NCBI | gene | 190397 | |||||
RefSeq | protein | NM_075119.5 | |||||
SwissProt | UniProtAcc | G5EGH7 | |||||
TREEFAM | TREEFAM_ID | TF353880 | |||||
UniProt_GCRP | UniProtAcc | G5EGH7 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lon | ||||||
Allele (210) | |||||||
Strain | WBStrain00023616 | ||||||
WBStrain00023617 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00020246 | ||||||
00020247 | |||||||
00020248 | |||||||
00020249 | |||||||
00020250 | |||||||
Ortholog (28) | |||||||
Structured_description | Concise_description | lon-8 encodes a secreted protein, conserved among nematodes, thatinhibits body elongation during larval and early adult growth, probablyby limiting cell size rather than nuclear ploidy or cell number; LON-8is also required for normal ray morphology in the male tail, but not forsuperficially normal male mating, suggesting a role in cuticleretraction; LON-8 is strongly expressed in the hypodermal syncytia hyp4and hyp7, and appears to be secreted from them in vivo; in males, LON-8is also expressed in male tail hypodermal nuclei (V6.pppaa, T.aa, R6.p,T.apapa, R7.p, R8.p and R9.p); LON-8 has no obvious non-nematodehomologs; LON-8 activity is genetically independent of DBL-1/TGF-betasignalling; newly hatched lon-8(hu187) larvae are normal in length, butthen outgrow wild-type larvae at a rate similar to that of lon-1(e185)larvae until 96 hours post-hatching, after which lon-8(hu187) growth wasnormal; lon-8(hu187) mutants have normal levels of hypodermalendoreduplication and of seam cell fusion; lon-8(hu187) is suppressed bymutations of dpy-11 or dpy-18; conversely, lon-8(hu187) does notsuppress dbl-1(nk3) or sma-6(e1482), and lon-8 transcripts are notaffected by dbl-1(nk3) or sma-6(e1482) mutations. | Paper_evidence | WBPaper00006395 | |||
WBPaper00029198 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 08 May 2007 00:00:00 | ||||||
Automated_description | Involved in nematode male tail tip morphogenesis and regulation of growth. Predicted to be located in extracellular space. Expressed in hyp4; hyp7 syncytium; and intestine. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | Y59A8B.20 | |||||
Corresponding_CDS_history | Y59A8B.20:wp125 | ||||||
Y59A8B.20:wp180 | |||||||
Corresponding_transcript | Y59A8B.20.1 | ||||||
Other_sequence (24) | |||||||
Associated_feature | WBsf669836 | ||||||
WBsf718465 | |||||||
WBsf1002797 | |||||||
WBsf1002798 | |||||||
WBsf1002799 | |||||||
WBsf1002800 | |||||||
WBsf1021381 | |||||||
WBsf1021382 | |||||||
WBsf1021383 | |||||||
WBsf1021384 | |||||||
Experimental_info | RNAi_result | WBRNAi00037626 | Inferred_automatically | RNAi_primary | |||
WBRNAi00057750 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00065819 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027541 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00026882 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00021164 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr4607 | ||||||
Expr4608 | |||||||
Expr1024390 | |||||||
Expr1035963 | |||||||
Expr1161172 | |||||||
Expr2013246 | |||||||
Expr2031477 | |||||||
Drives_construct | WBCnstr00012113 | ||||||
WBCnstr00012114 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (245) | |||||||
Interaction | WBInteraction000552655 | ||||||
WBInteraction000561993 | |||||||
WBInteraction000567986 | |||||||
Map_info | Map | V | Position | 13.4085 | Error | 0.008433 | |
Positive | Positive_clone | Y59A8B | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00029198 | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |