WormBase Tree Display for Gene: WBGene00013258

WBGene00013258 SMap: S_parent: Sequence: Y57A10A
  Identity: Version: 2
    Name: CGC_name: polg-1 Person_evidence: WBPerson8506
      Sequence_name: Y57A10A.15
      Molecular_name: Y57A10A.15
        Y57A10A.15.1
        CE25501
      Other_name: POLG Paper_evidence: WBPaper00048445
        CELE_Y57A10A.15 Accession_evidence: NDB BX284602
      Public_name: polg-1
    DB_info: Database: AceView gene 2M488
        WormQTL gene WBGene00013258
        WormFlux gene WBGene00013258
        NDB locus_tag CELE_Y57A10A.15
        Panther gene CAEEL|WormBase=WBGene00013258|UniProtKB=Q9U208
          family PTHR10267
        NCBI gene 174860
        RefSeq protein NM_064191.3
        TrEMBL UniProtAcc Q9U208
        UniProt_GCRP UniProtAcc Q9U208
        OMIM gene 174763
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 06 Apr 2009 15:16:23 WBPerson9133 Name_change: CGC_name: polg-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: polg
    Allele (437)
    Strain: WBStrain00036429
      WBStrain00026464
    RNASeq_FPKM (74)
    GO_annotation (20)
    Contained_in_operon: CEOP2688
    Ortholog (44)
    Structured_description: Concise_description: polg-1 encodes the C. elegans ortholog of human mitochondrial DNA polymerase gamma (POLG; OMIM:174763); polg-1 is required for normal levels of mitochondrial DNA during development, particularly during germ line development in late larval and adult stages; polg-1 is also required for normal brood sizes and adult lifespan. Paper_evidence: WBPaper00032530
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 29 Apr 2009 00:00:00
      Automated_description: Predicted to enable 3'-5' exonuclease activity and DNA-directed DNA polymerase activity. Involved in several processes, including defecation; determination of adult lifespan; and mitochondrial DNA replication. Predicted to be located in mitochondrion. Predicted to be part of gamma DNA polymerase complex. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); and ovarian disease (multiple). Is an ortholog of human POLG (DNA polymerase gamma, catalytic subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (15)
  Molecular_info: Corresponding_CDS: Y57A10A.15
    Corresponding_transcript: Y57A10A.15.1
    Other_sequence (48)
    Associated_feature: WBsf666231
      WBsf666232
      WBsf666233
      WBsf666234
      WBsf990029
      WBsf1013395
  Experimental_info: RNAi_result: WBRNAi00062465 Inferred_automatically: RNAi_primary
      WBRNAi00037557 Inferred_automatically: RNAi_primary
      WBRNAi00078299 Inferred_automatically: RNAi_primary
      WBRNAi00021097 Inferred_automatically: RNAi_primary
      WBRNAi00057617 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1010818
      Expr1035914
      Expr1161029
      Expr2014992
      Expr2033227
    Microarray_results (21)
    Expression_cluster (105)
    Interaction (22)
  Map_info: Map: II Position: 6.94169 Error: 0.019184
    Positive: Positive_clone: Y57A10A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene