| WBGene00013140 | SMap | S_parent | Sequence | Y53C12A |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | mop-25.2 | Person_evidence | WBPerson3760 |
| | | | | | WBPerson75 |
| | | Sequence_name | Y53C12A.4 |
| | | Molecular_name | Y53C12A.4 |
| | | | Y53C12A.4.1 |
| | | | CE14890 |
| | | Other_name | lss-18 | Paper_evidence | WBPaper00024980 |
| | | | | Person_evidence | WBPerson599 |
| | | | CELE_Y53C12A.4 | Accession_evidence | NDB | BX284602 |
| | | Public_name | mop-25.2 |
| | DB_info | Database | AceView | gene | 2J992 |
| | | | WormQTL | gene | WBGene00013140 |
| | | | WormFlux | gene | WBGene00013140 |
| | | | NDB | locus_tag | CELE_Y53C12A.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00013140|UniProtKB=O18211 |
| | | | | family | PTHR10182 |
| | | | NCBI | gene | 174527 |
| | | | RefSeq | protein | NM_063691.6 |
| | | | SwissProt | UniProtAcc | O18211 |
| | | | TREEFAM | TREEFAM_ID | TF314910 |
| | | | UniProt_GCRP | UniProtAcc | O18211 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 16 Feb 2007 14:39:36 | WBPerson2970 | Name_change | CGC_name | lss-18 |
| | | | 3 | 09 Mar 2007 14:55:52 | WBPerson2970 | Name_change | CGC_name | mop-25.2 |
| | | | | | | | Other_name | lss-18 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mop |
| | Allele (40) |
| | Strain | WBStrain00036879 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00031666 |
| | | 00031667 |
| | | 00031668 |
| | | 00031669 |
| | | 00031670 |
| | | 00031671 |
| | | 00031672 |
| | | 00031673 |
| | | 00031674 |
| | Contained_in_operon | CEOP2448 |
| | Ortholog (46) |
| | Paralog | WBGene00020858 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00019827 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | mop-25.2 encodes a Mo25 protein that inhibits DHC-1 in vivo; MOP-25.2 is orthologous to fission yeast Mo25p, budding yeast Hym1p, Aspergillus nidulans HymA, human CAB39, and human CAB39L; MOP-25.2 is paralogous to MOP-25.1 and (more distantly) MOP-25.3; mop-25.2(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that MOP-25.2 negatively regulates dynein; in early embryos, MOP-25.2 is associated with the midbody and spindle poles after cytokinesis; MOP-25.2 shares a redundant function with MOP-25.1 in fertility and embryonic viability; in mass RNAi assays, MOP-25.2 is required for normal locomotion, body coloration, speed, and body size. | Paper_evidence | WBPaper00005654 |
| | | | | | WBPaper00006395 |
| | | | | | WBPaper00028381 |
| | | | | | WBPaper00030897 |
| | | | | | WBPaper00030911 |
| | | | | | WBPaper00030914 |
| | | | | | WBPaper00030918 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 28 Aug 2007 00:00:00 |
| | | Automated_description | Predicted to enable protein serine/threonine kinase activator activity. Involved in asymmetric neuroblast division. Predicted to be located in cytoplasm and spindle pole. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and pancreatic cancer. Is an ortholog of human CAB39 (calcium binding protein 39) and CAB39L (calcium binding protein 39 like). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20292) |
| | | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20292) |
| Molecular_info | Corresponding_CDS | Y53C12A.4 |
| | Corresponding_transcript | Y53C12A.4.1 |
| | Other_sequence (17) |
| | Associated_feature | WBsf650452 |
| | | WBsf223691 |
| | | WBsf223692 |
| | | WBsf223693 |
| Experimental_info | RNAi_result (11) |
| | Expr_pattern | Expr4804 |
| | | Expr1012408 |
| | | Expr1035832 |
| | | Expr1160688 |
| | | Expr2013662 |
| | | Expr2031896 |
| | Drives_construct | WBCnstr00029748 |
| | Construct_product | WBCnstr00001414 |
| | | WBCnstr00029748 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037682:sma-2_downregulated |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:excretory-cell_larva_enriched |
| | | WBPaper00037950:excretory-cell_larva_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045316:prg-1_upregulated_L2 |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00054626:NO_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00060224:atf-6(ok551)_downregulated |
| | | WBPaper00060871:M.humicola-infection_24h_regulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:cdc-42_17192-rab-5_18073 |
| | | WBPaper00061527:cids-2_2203-attf-2_2451 |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062590:Aging_upregulated_intestine |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_3_6 |
| | | cgc4489_group_5 |
| | | WBPaper00025032:cluster_20 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040963:TA100_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:intrinsic |
| | Interaction (22) |
| Map_info | Map | II | Position | 1.65744 | Error | 0.002286 |
| | Positive | Positive_clone | Y53C12A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00028381 |
| | WBPaper00030897 |
| | WBPaper00034036 |
| | WBPaper00038491 |
| | WBPaper00038846 |
| | WBPaper00041303 |
| | WBPaper00041850 |
| | WBPaper00055090 |
| | WBPaper00055221 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
