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WormBase Tree Display for Gene: WBGene00012448

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Name Class

WBGene00012448SMapS_parentSequenceCHROMOSOME_V
IdentityVersion2
NameCGC_namecyp-33D3
Sequence_nameY17D7A.4
Molecular_nameY17D7A.4
Y17D7A.4.1
CE16589
Other_nameCELE_Y17D7A.4Accession_evidenceNDBBX284605
Public_namecyp-33D3
DB_infoDatabaseAceViewgene5T310
WormQTLgeneWBGene00012448
WormFluxgeneWBGene00012448
NDBlocus_tagCELE_Y17D7A.4
PanthergeneCAEEL|WormBase=WBGene00012448|UniProtKB=G5EE22
familyPTHR24300
NCBIgene189444
RefSeqproteinNM_075278.4
TrEMBLUniProtAccG5EE22
UniProt_GCRPUniProtAccG5EE22
OMIMgene601130
608713
610670
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:53WBPerson1971EventImportedInitial conversion from CDS class of WS125
221 Sep 2004 09:38:16WBPerson1971Name_changeCGC_namecyp-33D3
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcyp
Allele (116)
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (114)
Paralog (44)
Structured_descriptionAutomated_descriptionPredicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Keshan disease; glucose metabolism disease (multiple); and hematologic cancer (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2C19 (cytochrome P450 family 2 subfamily C member 19); and CYP2C8 (cytochrome P450 family 2 subfamily C member 8).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (46)
Molecular_infoCorresponding_CDSY17D7A.4
Corresponding_CDS_historyY17D7A.4:wp106
Corresponding_transcriptY17D7A.4.1
Other_sequence (20)
Associated_featureWBsf982076
WBsf1003019
WBsf1021557
Experimental_infoRNAi_resultWBRNAi00036657Inferred_automaticallyRNAi_primary
WBRNAi00092667Inferred_automaticallyRNAi_primary
WBRNAi00055560Inferred_automaticallyRNAi_primary
WBRNAi00095077Inferred_automaticallyRNAi_primary
Expr_patternExpr1021931
Expr1159061
Expr2010722
Expr2028960
Microarray_results (15)
Expression_clusterWBPaper00031040:TGF-beta_adult_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
WBPaper00042194:nhr-114(RNAi)_downregulated
WBPaper00044030:nhr-8(hd117)_upregulated
WBPaper00045390:tunicamycin_downregulated
WBPaper00045774:clk-1_upregulated
WBPaper00045774:clk-1_upregulated_CoQ10_dependent
WBPaper00046805:csr-1(RNAi)_upregulated_Set1
WBPaper00046805:csr-1(RNAi)_upregulated_Set2
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048923:Aging_regulated
WBPaper00050096:P.aeruginosa_downregulated
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053402:cco-1(RNAi)_upregulated
WBPaper00053771:up_at_24h-NaCl
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055137:S.maltophilia_downregulated
WBPaper00055354:Allantoin_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Metformin_upregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Psora_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin-Psora_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00055971:nhl-2(ok818)_20C_upregulated
WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00059605:mut-16(pk710)_downregulated
WBPaper00059754:E.faecalis_OG1RF_upregulated
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00060399:CoCl2_6hr_downregulated_N2
WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
WBPaper00060445:ikb-1(nr2027)_upregulated_L1
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061357:mett-10(ok2204)_upregulated_OP50
WBPaper00061390:N2_ascarosides_downregulated
WBPaper00061424:Diet_MYb131_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:gst-26-pho-1_10767
WBPaper00061530:nhr-49(e2144)_downregulated
WBPaper00061753:csr-1(tor159)_downregulated_20C
WBPaper00061753:csr-1(tor159)_upregulated_25C
WBPaper00062056:lin-36(we36)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064769:him-17(me24)_upregulated
WBPaper00064788:ketamine_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065288:mdt-15(tm2182)_downregulated
WBPaper00065841:15_0
WBPaper00065849:ursolic-acid_regulated
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066110:Cisplatin_upregulated_tetraploid
WBPaper00066118:cyclobutrifluram_downregulated
WBPaper00066232:ash-2(RNAi)_downregulated_WT
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041609:hpl-1_hpl-2_downregulated
WBPaper00041939:control_vs_EtBr-exposed_3h
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045673:colistin_upregulated
WBPaper00056330:mrps-5(RNAi)_upregulated
Interaction (35)
Map_infoMapVPosition18.0657Error0.02692
PositivePositive_cloneY17D7AInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00038491
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene