T28B11.1 encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp1 or with other proteins; about 5% to 15% of T28B11.1 transcripts are RNA edited to change A to G resulting in a change to residue 369 from an K to a E.
Enriched in coelomocyte; germ line; mc3; neurons; and ventral nerve cord based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-12; and hsf-1 based on tiling array; microarray; and RNA-seq studies. Is affected by fifteen chemicals including Cry5B; Zidovudine; and Rifampin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: F-box domain; F-box-like domain superfamily; and Phosphorylation site.