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WormBase Tree Display for Gene: WBGene00012005

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Name Class

WBGene00012005SMapS_parentSequenceCHROMOSOME_II
IdentityVersion4
NameCGC_namejun-1Person_evidenceWBPerson2962
WBPerson443
Sequence_nameT24H10.7
Molecular_name (27)
Other_nameCELE_T24H10.7Accession_evidenceNDBBX284602
Public_namejun-1
DB_infoDatabase (10)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:53WBPerson1971EventImportedInitial conversion from CDS class of WS125
229 Nov 2004 12:57:28WBPerson1983EventAcquires_mergeWBGene00012001
327 Apr 2007 10:10:56WBPerson1983EventAcquires_mergeWBGene00012006
407 Nov 2007 09:36:21WBPerson2970Name_changeCGC_namejun-1
Acquires_mergeWBGene00012001
WBGene00012006
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classjun
Allele (304)
StrainWBStrain00036395
WBStrain00036410
RNASeq_FPKM (74)
GO_annotation (28)
Contained_in_operonCEOP2709
Ortholog (31)
Structured_descriptionConcise_descriptionjun-1 encodes a basic-leucine zipper (bZIP) transcription factor that is the C. elegans JUN homolog; jun-1 activity is essential for regulation of ovulation, and thus normal levels of fertility; in regulating ovulation, JUN-1 functions with FOS-1 to regulate expression of plc-1 which encodes a phospholipase C essential for IP3 production and ovulation; in addition, JUN-1 interacts with FOS-1 in vitro to form heterodimers capable of binding upstream regulatory sequences of egl-13, which encodes a transcription factor required for uterine cell fate specification; jun-1 is expressed in the uterus and the spermatheca.Paper_evidenceWBPaper00031111
WBPaper00034689
Curator_confirmedWBPerson1843
Date_last_updated19 Jan 2010 00:00:00
Automated_descriptionEnables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of RNA splicing; and response to starvation. Located in nucleus. Expressed in several structures, including excretory cell; hermaphrodite gonad; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and lymphoma (multiple). Is an ortholog of human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); and JUND (JunD proto-oncogene, AP-1 transcription factor subunit).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (22)
Molecular_infoCorresponding_CDST24H10.7a
T24H10.7b
T24H10.7c
T24H10.7d
T24H10.7e
T24H10.7f
T24H10.7g
T24H10.7h
T24H10.7i
Corresponding_CDS_historyT24H10.7:wp136
Corresponding_transcriptT24H10.7a.1
T24H10.7b.1
T24H10.7c.1
T24H10.7d.1
T24H10.7e.1
T24H10.7f.1
T24H10.7g.1
T24H10.7h.1
T24H10.7i.1
Other_sequence (42)
Associated_feature (34)
Gene_product_binds (375)
Transcription_factorWBTranscriptionFactor000109
WBTranscriptionFactor000501
Experimental_infoRNAi_result (33)
Expr_pattern (14)
Drives_constructWBCnstr00012826
WBCnstr00014260
WBCnstr00014283
WBCnstr00014284
WBCnstr00014288
WBCnstr00014300
WBCnstr00014302
WBCnstr00030207
Construct_productWBCnstr00030207
Microarray_results (48)
Expression_cluster (184)
InteractionWBInteraction000006187
WBInteraction000008342
WBInteraction000008343
WBInteraction000008344
WBInteraction000008345
WBInteraction000519883
WBInteraction000523820
WBInteraction000523821
WBInteraction000523822
WBInteraction000524757
WBInteraction000524759
WBInteraction000526368
WBInteraction000526369
WBInteraction000526370
WBInteraction000526371
WBInteraction000526372
WBInteraction000526373
WBInteraction000526374
WBInteraction000526375
WBInteraction000526376
WBInteraction000526377
WBInteraction000526378
WBInteraction000526379
WBInteraction000526380
WBInteraction000526381
WBInteraction000526382
WBInteraction000526383
WBInteraction000526384
WBInteraction000526385
WBInteraction000526386
WBInteraction000526387
WBInteraction000526388
WBInteraction000526389
WBInteraction000534982
WBInteraction000540015
WBInteraction000540991
WBInteraction000541101
WBInteraction000541102
WBInteraction000541104
WBInteraction000544679
WBInteraction000544716
WBInteraction000544725
WBInteraction000545935
WBInteraction000547436
WBInteraction000560583
WBInteraction000561392
Map_infoMapIIPosition1.04759Error0.001496
PositivePositive_cloneT24H10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (24)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene