WormBase Tree Display for Gene: WBGene00012005
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WBGene00012005 | SMap | S_parent | Sequence | CHROMOSOME_II | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | jun | ||||||
Allele (304) | |||||||
Strain | WBStrain00036395 | ||||||
WBStrain00036410 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (28) | |||||||
Contained_in_operon | CEOP2709 | ||||||
Ortholog (31) | |||||||
Structured_description | Concise_description | jun-1 encodes a basic-leucine zipper (bZIP) transcription factor that is the C. elegans JUN homolog; jun-1 activity is essential for regulation of ovulation, and thus normal levels of fertility; in regulating ovulation, JUN-1 functions with FOS-1 to regulate expression of plc-1 which encodes a phospholipase C essential for IP3 production and ovulation; in addition, JUN-1 interacts with FOS-1 in vitro to form heterodimers capable of binding upstream regulatory sequences of egl-13, which encodes a transcription factor required for uterine cell fate specification; jun-1 is expressed in the uterus and the spermatheca. | Paper_evidence | WBPaper00031111 | |||
WBPaper00034689 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 19 Jan 2010 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of RNA splicing; and response to starvation. Located in nucleus. Expressed in several structures, including excretory cell; hermaphrodite gonad; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and lymphoma (multiple). Is an ortholog of human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); and JUND (JunD proto-oncogene, AP-1 transcription factor subunit). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (22) | ||||||
Molecular_info | Corresponding_CDS | T24H10.7a | |||||
T24H10.7b | |||||||
T24H10.7c | |||||||
T24H10.7d | |||||||
T24H10.7e | |||||||
T24H10.7f | |||||||
T24H10.7g | |||||||
T24H10.7h | |||||||
T24H10.7i | |||||||
Corresponding_CDS_history | T24H10.7:wp136 | ||||||
Corresponding_transcript | T24H10.7a.1 | ||||||
T24H10.7b.1 | |||||||
T24H10.7c.1 | |||||||
T24H10.7d.1 | |||||||
T24H10.7e.1 | |||||||
T24H10.7f.1 | |||||||
T24H10.7g.1 | |||||||
T24H10.7h.1 | |||||||
T24H10.7i.1 | |||||||
Other_sequence (42) | |||||||
Associated_feature (34) | |||||||
Gene_product_binds (375) | |||||||
Transcription_factor | WBTranscriptionFactor000109 | ||||||
WBTranscriptionFactor000501 | |||||||
Experimental_info | RNAi_result (33) | ||||||
Expr_pattern (14) | |||||||
Drives_construct | WBCnstr00012826 | ||||||
WBCnstr00014260 | |||||||
WBCnstr00014283 | |||||||
WBCnstr00014284 | |||||||
WBCnstr00014288 | |||||||
WBCnstr00014300 | |||||||
WBCnstr00014302 | |||||||
WBCnstr00030207 | |||||||
Construct_product | WBCnstr00030207 | ||||||
Microarray_results (48) | |||||||
Expression_cluster (184) | |||||||
Interaction (46) | |||||||
Map_info | Map | II | Position | 1.04759 | Error | 0.001496 | |
Positive | Positive_clone | T24H10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (24) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |