WormBase Tree Display for Gene: WBGene00011995

WBGene00011995 SMap: S_parent: Sequence: T24F1
  Identity: Version: 3
    Name: CGC_name: rsf-1 Paper_evidence: WBPaper00041685
          Person_evidence: WBPerson3250
      Sequence_name: T24F1.3
      Molecular_name: T24F1.3a
        T24F1.3a.1
        CE02363
        T24F1.3b
        CE38227
        T24F1.3b.1
        T24F1.3b.2
      Other_name: rasf-1 Paper_evidence: WBPaper00041898
        CELE_T24F1.3 Accession_evidence: NDB BX284602
      Public_name: rsf-1
    DB_info: Database: AceView gene 2L601
        WormQTL gene WBGene00011995
        WormFlux gene WBGene00011995
        NDB locus_tag CELE_T24F1.3
        Panther gene CAEEL|WormBase=WBGene00011995|UniProtKB=Q22744
          family PTHR22738
        NCBI gene 174728
        RefSeq protein NM_001383950.2
            NM_001027190.5
        SwissProt UniProtAcc Q22744
        TREEFAM TREEFAM_ID TF319243
        UniProt_GCRP UniProtAcc Q22744
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 02 Nov 2012 15:46:40 WBPerson2970 Name_change: CGC_name: rsf-1
        3 22 Jan 2013 16:28:28 WBPerson2970 Name_change: Other_name: rasf-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rsf
    Allele (96)
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (52)
    Structured_description: Concise_description: rsf-1 encodes the C. elegans homolog of the Ras-association domain family protein 1 (RASSF1); genetic analysis indicates that rsf-1 activity is required for embryonic development and morphogenesis and may play a role in regulating Ras signal transduction; RSF-1 physically interacts with CST-1 and CST-2, C. elegans Sterile 20 kinase homologs; an rsf-1::gfp reporter fusion is expressed in epithelial cells during dorsal intercalation and ventral enclosure; in postembryonic animals, an rsf-1::gfp reporter fusion is expressed in a number of tissues including the pharynx, epithelial cells, neurons, body wall muscles, the hypodermis, vulva, gonadal sheath cells, and tail hypodermis. Paper_evidence: WBPaper00041685
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Dec 2012 00:00:00
      Automated_description: Enables small GTPase binding activity. Involved in several processes, including organelle organization; positive regulation of response to oxidative stress; and regulation of vulval development. Predicted to be located in cytoplasm and microtubule. Expressed in pharynx and vulva. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Is an ortholog of human RASSF1 (Ras association domain family member 1) and RASSF5 (Ras association domain family member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9882)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17609,HGNC:9882)
      DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9882)
      DOID:2671 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9882)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9882)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9882)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9882)
      DOID:4362 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9882)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9882)
  Molecular_info: Corresponding_CDS: T24F1.3a
      T24F1.3b
    Corresponding_transcript: T24F1.3a.1
      T24F1.3b.1
      T24F1.3b.2
    Other_sequence (51)
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00019169 Inferred_automatically: RNAi_primary
      WBRNAi00112236 Inferred_automatically: RNAi_primary
      WBRNAi00054074 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr10715
      Expr1012303
      Expr1035302
      Expr1157618
      Expr2015553
      Expr2033788
    Drives_construct: WBCnstr00015541
      WBCnstr00017490
      WBCnstr00017491
      WBCnstr00030215
    Construct_product: WBCnstr00015541
      WBCnstr00017491
      WBCnstr00030215
    Microarray_results (25)
    Expression_cluster (149)
    Interaction (34)
  Map_info: Map: II Position: 3.411
    Positive: Positive_clone: T24F1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00041685
    WBPaper00041898
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene