WormBase Tree Display for Gene: WBGene00011995
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| WBGene00011995 | SMap | S_parent | Sequence | T24F1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | rsf-1 | Paper_evidence | WBPaper00041685 | |||||
| Person_evidence | WBPerson3250 | ||||||||
| Sequence_name | T24F1.3 | ||||||||
| Molecular_name | T24F1.3a | ||||||||
| T24F1.3a.1 | |||||||||
| CE02363 | |||||||||
| T24F1.3b | |||||||||
| CE38227 | |||||||||
| T24F1.3b.1 | |||||||||
| T24F1.3b.2 | |||||||||
| Other_name | rasf-1 | Paper_evidence | WBPaper00041898 | ||||||
| CELE_T24F1.3 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | rsf-1 | ||||||||
| DB_info | Database | AceView | gene | 2L601 | |||||
| WormQTL | gene | WBGene00011995 | |||||||
| WormFlux | gene | WBGene00011995 | |||||||
| NDB | locus_tag | CELE_T24F1.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00011995|UniProtKB=Q22744 | |||||||
| family | PTHR22738 | ||||||||
| NCBI | gene | 174728 | |||||||
| RefSeq | protein | NM_001383950.2 | |||||||
| NM_001027190.5 | |||||||||
| SwissProt | UniProtAcc | Q22744 | |||||||
| TREEFAM | TREEFAM_ID | TF319243 | |||||||
| UniProt_GCRP | UniProtAcc | Q22744 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 02 Nov 2012 15:46:40 | WBPerson2970 | Name_change | CGC_name | rsf-1 | ||||
| 3 | 22 Jan 2013 16:28:28 | WBPerson2970 | Name_change | Other_name | rasf-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rsf | ||||||||
| Allele (96) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (52) | |||||||||
| Structured_description | Concise_description | rsf-1 encodes the C. elegans homolog of the Ras-association domain family protein 1 (RASSF1); genetic analysis indicates that rsf-1 activity is required for embryonic development and morphogenesis and may play a role in regulating Ras signal transduction; RSF-1 physically interacts with CST-1 and CST-2, C. elegans Sterile 20 kinase homologs; an rsf-1::gfp reporter fusion is expressed in epithelial cells during dorsal intercalation and ventral enclosure; in postembryonic animals, an rsf-1::gfp reporter fusion is expressed in a number of tissues including the pharynx, epithelial cells, neurons, body wall muscles, the hypodermis, vulva, gonadal sheath cells, and tail hypodermis. | Paper_evidence | WBPaper00041685 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Dec 2012 00:00:00 | ||||||||
| Automated_description | Enables small GTPase binding activity. Involved in several processes, including organelle organization; positive regulation of response to oxidative stress; and regulation of vulval development. Predicted to be located in cytoplasm and microtubule. Expressed in pharynx and vulva. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Is an ortholog of human RASSF1 (Ras association domain family member 1) and RASSF5 (Ras association domain family member 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9882) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17609,HGNC:9882) | ||||||
| DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9882) | ||||||
| DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9882) | ||||||
| DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9882) | ||||||
| DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9882) | ||||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9882) | ||||||
| DOID:4362 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9882) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9882) | ||||||
| Molecular_info | Corresponding_CDS | T24F1.3a | |||||||
| T24F1.3b | |||||||||
| Corresponding_transcript | T24F1.3a.1 | ||||||||
| T24F1.3b.1 | |||||||||
| T24F1.3b.2 | |||||||||
| Other_sequence (51) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00019169 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00112236 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054074 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr10715 | ||||||||
| Expr1012303 | |||||||||
| Expr1035302 | |||||||||
| Expr1157618 | |||||||||
| Expr2015553 | |||||||||
| Expr2033788 | |||||||||
| Drives_construct | WBCnstr00015541 | ||||||||
| WBCnstr00017490 | |||||||||
| WBCnstr00017491 | |||||||||
| WBCnstr00030215 | |||||||||
| Construct_product | WBCnstr00015541 | ||||||||
| WBCnstr00017491 | |||||||||
| WBCnstr00030215 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction | WBInteraction000158448 | ||||||||
| WBInteraction000158832 | |||||||||
| WBInteraction000159261 | |||||||||
| WBInteraction000162490 | |||||||||
| WBInteraction000162640 | |||||||||
| WBInteraction000162654 | |||||||||
| WBInteraction000164252 | |||||||||
| WBInteraction000166678 | |||||||||
| WBInteraction000167516 | |||||||||
| WBInteraction000167622 | |||||||||
| WBInteraction000167623 | |||||||||
| WBInteraction000169668 | |||||||||
| WBInteraction000169675 | |||||||||
| WBInteraction000197474 | |||||||||
| WBInteraction000225804 | |||||||||
| WBInteraction000238234 | |||||||||
| WBInteraction000243141 | |||||||||
| WBInteraction000260402 | |||||||||
| WBInteraction000292062 | |||||||||
| WBInteraction000295020 | |||||||||
| WBInteraction000339774 | |||||||||
| WBInteraction000342992 | |||||||||
| WBInteraction000361638 | |||||||||
| WBInteraction000372731 | |||||||||
| WBInteraction000374241 | |||||||||
| WBInteraction000409375 | |||||||||
| WBInteraction000439646 | |||||||||
| WBInteraction000441423 | |||||||||
| WBInteraction000447055 | |||||||||
| WBInteraction000456285 | |||||||||
| WBInteraction000519679 | |||||||||
| WBInteraction000557706 | |||||||||
| WBInteraction000583782 | |||||||||
| WBInteraction000584187 | |||||||||
| Map_info | Map | II | Position | 3.411 | |||||
| Positive | Positive_clone | T24F1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00041685 | |||||||||
| WBPaper00041898 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
