WormBase Tree Display for Gene: WBGene00011908
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| WBGene00011908 | SMap | S_parent | Sequence | T22A3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pash-1 | Person_evidence | WBPerson490 | |||||
| Sequence_name | T22A3.5 | ||||||||
| Molecular_name | T22A3.5a | ||||||||
| T22A3.5a.1 | |||||||||
| CE48538 | |||||||||
| T22A3.5b | |||||||||
| CE48740 | |||||||||
| T22A3.5b.1 | |||||||||
| Other_name | CELE_T22A3.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | pash-1 | ||||||||
| DB_info | Database | AceView | gene | 1L181 | |||||
| WormQTL | gene | WBGene00011908 | |||||||
| WormFlux | gene | WBGene00011908 | |||||||
| OMIM | disease | 611867 | |||||||
| gene | 609030 | ||||||||
| NDB | locus_tag | CELE_T22A3.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00011908|UniProtKB=U4PRH5 | |||||||
| family | PTHR13482 | ||||||||
| NCBI | gene | 172950 | |||||||
| RefSeq | protein | NM_001306533.3 | |||||||
| NM_001306532.2 | |||||||||
| TrEMBL | UniProtAcc | U4PEM4 | |||||||
| U4PRH5 | |||||||||
| UniProt_GCRP | UniProtAcc | U4PRH5 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 04 Nov 2004 11:21:33 | WBPerson2970 | Name_change | CGC_name | pash-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pash | ||||||||
| Allele (90) | |||||||||
| Strain | WBStrain00028979 | ||||||||
| WBStrain00034645 | |||||||||
| WBStrain00050747 | |||||||||
| WBStrain00050761 | |||||||||
| WBStrain00050760 | |||||||||
| WBStrain00052586 | |||||||||
| In_cluster | conserved_miRNA_siRNA_cluster | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | pash-1 encodes an RNA-binding protein that is orthologous to Drosophila Pasha and mammalian DGCR8; pash-1 activity is required for processing of primary miRNA transripts (pri-miRNAs), such as that of let-7, to generate pre-miRNAs that will then be processed by DCR-1 to generate mature miRNAs; accordingly, pash-1 mutants show defects in let-7-mediated developmental processes, namely the transition from late larval to adult cell fates. | Paper_evidence | WBPaper00024573 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 18 May 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Involved in primary miRNA processing and regulation of developmental process. Predicted to be part of microprocessor complex. Expressed in head; hypodermis; intestine; marginal cell; and pharyngeal muscle cell. Used to study chromosome 22q11.2 deletion syndrome, distal. Is an ortholog of human DGCR8 (DGCR8 microprocessor complex subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:0050741 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2847) | |||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including DGCR8 (DGCR8 microprocessor complex subunit, also called DiGeorge syndrome critical region gene 8); both human DGCR8 and the C. elegans ortholog pash-1, are involoved in primary microRNA processing and thus microRNA maturation and microRNA-mediated gene regulation; knockdown phenotypes of pash-1 include reduced microRNA processing, decreased life-span, enhanced locomotor defects of the Unc phenotype and vulva defects. | Homo sapiens | Paper_evidence | WBPaper00047004 | |||||
| WBPaper00041677 | |||||||||
| WBPaper00024573 | |||||||||
| Accession_evidence | OMIM | 611867 | |||||||
| 609030 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000372 | ||||||||
| Molecular_info | Corresponding_CDS | T22A3.5a | |||||||
| T22A3.5b | |||||||||
| Corresponding_CDS_history | T22A3.5:wp239 | ||||||||
| Corresponding_transcript | T22A3.5a.1 | ||||||||
| T22A3.5b.1 | |||||||||
| Other_sequence | CJC09477_1 | ||||||||
| CJC07777_1 | |||||||||
| CBC10852_1 | |||||||||
| CBC09698_1 | |||||||||
| EL889867.1 | |||||||||
| Associated_feature | WBsf643702 | ||||||||
| WBsf985045 | |||||||||
| WBsf218464 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr11294 | ||||||||
| Expr1017527 | |||||||||
| Expr1035253 | |||||||||
| Expr1157325 | |||||||||
| Expr2014747 | |||||||||
| Expr2032981 | |||||||||
| Drives_construct | WBCnstr00018744 | ||||||||
| WBCnstr00030293 | |||||||||
| Construct_product | WBCnstr00017327 | ||||||||
| WBCnstr00030293 | |||||||||
| Antibody | WBAntibody00002679 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (152) | |||||||||
| Interaction | WBInteraction000049918 | ||||||||
| WBInteraction000050732 | |||||||||
| WBInteraction000164470 | |||||||||
| WBInteraction000502008 | |||||||||
| WBInteraction000519133 | |||||||||
| WBInteraction000520386 | |||||||||
| WBInteraction000575441 | |||||||||
| Anatomy_function | WBbtf0565 | ||||||||
| WBbtf0566 | |||||||||
| WBbtf0567 | |||||||||
| WBbtf0568 | |||||||||
| WBbtf0569 | |||||||||
| WBbtf0570 | |||||||||
| WBProcess | WBbiopr:00000057 | ||||||||
| WBbiopr:00000081 | |||||||||
| Map_info | Map | I | Position | 5.05848 | Error | 0.000319 | |||
| Positive | Positive_clone | T22A3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5599 | |||||||
| 5267 | |||||||||
| 5545 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (22) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
