WormBase Tree Display for Gene: WBGene00011676

WBGene00011676 SMap: S_parent: Sequence: T10B9
  Identity: Version: 2
    Name: CGC_name: cyp-13A2
      Sequence_name: T10B9.7
      Molecular_name: T10B9.7
        T10B9.7.1
        CE01659
      Other_name: CELE_T10B9.7 Accession_evidence: NDB BX284602
      Public_name: cyp-13A2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-13A2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (68)
    RNASeq_FPKM (74)
    GO_annotation: 00079959
      00079960
      00079961
      00118915
      00118916
      00118917
      00118918
    Contained_in_operon: CEOP2766
    Ortholog (80)
    Paralog (12)
    Structured_description: Concise_description: cyp-13A2 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates. Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Nov 2008 00:00:00
      Automated_description: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; familial Mediterranean fever; and leukemia (multiple). Is an ortholog of several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A5 (cytochrome P450 family 3 subfamily A member 5); and CYP3A7 (cytochrome P450 family 3 subfamily A member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:8552 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2638)
      DOID:3526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11609)
      DOID:2987 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2637)
      DOID:9952 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2638)
      DOID:0112251 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11609)
      DOID:0080630 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2638)
      DOID:10825 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2638)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2637)
  Molecular_info: Corresponding_CDS: T10B9.7
    Corresponding_transcript: T10B9.7.1
    Other_sequence (11)
    Associated_feature: WBsf650458
      WBsf650459
      WBsf989147
      WBsf989148
      WBsf1012903
      WBsf1012904
  Experimental_info: RNAi_result: WBRNAi00035425 Inferred_automatically: RNAi_primary
      WBRNAi00092621 Inferred_automatically: RNAi_primary
      WBRNAi00018528 Inferred_automatically: RNAi_primary
      WBRNAi00053020 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1025189
      Expr1156620
      Expr2010682
      Expr2028922
    Drives_construct: WBCnstr00030477
    Construct_product: WBCnstr00030477
    Microarray_results (20)
    Expression_cluster: WBPaper00032425:up_in_rde-4
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040560:hpl-2_embryo_downregulated
      WBPaper00042194:Tryptophan_upregulated
      WBPaper00044005:DAF-16_downregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044426:rotenone_5day_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00047131:daf-2(e1370)_downregulated_N2-background
      WBPaper00048690:hermaphrodite-Z1-Z4_enriched
      WBPaper00048690:male-Z1-Z4-daughter_enriched
      WBPaper00048690:male-Z1-Z4_enriched
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00049018:swsn-2.2(RNAi)_upregulated
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049736:15deg-then-25deg(12hr)_upregulated_N2
      WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:hyl-2(tm2031)_upregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPA_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051039:intestine_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051265:F1_hrde-1(tm1200)_upregulated
      WBPaper00051265:F1_morc-1(tm6048)_upregulated
      WBPaper00051388:Glucose-diet_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00054192:cold-shock_downregulated
      WBPaper00054410:set-9(rw5)_upregulated
      WBPaper00054410:set-26(tm2467)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056073:R24_upregulated_nhr-86_dependent
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056284:ints-6(t1903)_upregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056826:SGP_biased
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059194:klf-1(RNAi)_regulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060526:plp-1(ok2155)_upregulated
      WBPaper00060661:hypoxia_downregulated
      WBPaper00060703:nas-38(ok3407)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061040:eat-2(ad1116)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061340:B
      WBPaper00061340:F_U
      WBPaper00061340:hyp3
      WBPaper00061340:T
      WBPaper00061340:URA_parent
      WBPaper00061340:Z1_Z4
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:gst-26-pho-1_10767
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00061952:daf-18(nr2037)_upregulated
      WBPaper00061952:daf-18(yh1)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:daf-16(RNAi)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062590:Aging_downregulated_body-wall-muscle
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00062606:rotenone_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064291:antimycin_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064632:daf-2(e1370)_downregulated_intestine
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064871:PA14_downregulated_AWA
      WBPaper00064952:Day1_vs_L4_downregulated_20C
      WBPaper00064952:Day1_vs_L4_downregulated_25C
      WBPaper00064952:Day5_vs_L4_downregulated_20C
      WBPaper00064952:Day5_vs_L4_downregulated_25C
      WBPaper00064952:Day10_vs_L4_downregulated_20C
      WBPaper00064952:Day10_vs_L4_downregulated_25C
      WBPaper00065005:sams-4(RNAi)_upregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065841:9_0
      WBPaper00065841:9_1
      WBPaper00065841:9_2
      WBPaper00065841:24_0
      WBPaper00065841:24_1
      WBPaper00065841:30_1
      WBPaper00065841:57_0
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_transcript
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066204:CdCl2_upregulated_mRNA
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_5
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026952:class_D
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037695:WC_5-day
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2down
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040876:mir-35_upregulated
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045015:nhr-25(RNAi)_downregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5376]:let-60(G12V)-regulated_genes
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_B
      [cgc6390]:mixed_spermatogenesis-somatic
    Interaction (28)
  Map_info: Map: II Position: 1.71406 Error: 0.000287
    Positive: Positive_clone: T10B9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00026952
    WBPaper00038491
    WBPaper00042257
    WBPaper00055090
    WBPaper00064598
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene