WormBase Tree Display for Gene: WBGene00011480
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| WBGene00011480 | SMap | S_parent | Sequence | T05E11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | enpl-1 | Person_evidence | WBPerson304 | |||||
| Sequence_name | T05E11.3 | ||||||||
| Molecular_name | T05E11.3a | ||||||||
| T05E11.3a.1 | |||||||||
| CE06362 | |||||||||
| T05E11.3b | |||||||||
| CE45764 | |||||||||
| T05E11.3a.2 | |||||||||
| T05E11.3b.1 | |||||||||
| Other_name | CELE_T05E11.3 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | enpl-1 | ||||||||
| DB_info | Database | AceView | gene | 4L887 | |||||
| WormQTL | gene | WBGene00011480 | |||||||
| WormFlux | gene | WBGene00011480 | |||||||
| NDB | locus_tag | CELE_T05E11.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00011480|UniProtKB=Q22235 | |||||||
| family | PTHR11528 | ||||||||
| NCBI | gene | 178014 | |||||||
| RefSeq | protein | NM_001268607.4 | |||||||
| NM_001268608.3 | |||||||||
| SwissProt | UniProtAcc | Q22235 | |||||||
| TREEFAM | TREEFAM_ID | TF105969 | |||||||
| UniProt_GCRP | UniProtAcc | Q22235 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 31 Aug 2012 11:56:39 | WBPerson2970 | Name_change | CGC_name | enpl-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | enpl | ||||||||
| Allele (44) | |||||||||
| Possibly_affected_by | WBVar02153291 | ||||||||
| Strain | WBStrain00037295 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00000915 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00020110 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | enpl-1 encodes the C. elegans ortholog of the Hsp90 family member and endoplasmic reticulum (ER) chaperone GRP94/GP96; loss of enpl-1 activity via RNAi results in slow growth, larval arrest, uncoordinated locomotion, and weak endocytosis defects; in addition, loss of enpl-1 expression results in an increase in hsp-4 expression, revealing compensatory regulation amongst ER chaperones; an enpl-1::gfp reporter fusion is expressed in the pharynx, with large-scale expression studies reporting additional expression in the intestine and several unidentified cells in the head. | Paper_evidence | WBPaper00003992 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00006395 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00025202 | |||||||||
| WBPaper00030951 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Oct 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Expressed in head; neurons; pharynx; and vulva. Human ortholog(s) of this gene implicated in lung adenocarcinoma. Is an ortholog of human HSP90B1 (heat shock protein 90 beta family member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12028) | ||||
| Molecular_info | Corresponding_CDS | T05E11.3a | |||||||
| T05E11.3b | |||||||||
| Corresponding_transcript | T05E11.3a.1 | ||||||||
| T05E11.3a.2 | |||||||||
| T05E11.3b.1 | |||||||||
| Other_sequence (237) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Chronogram787 | ||||||||
| Expr1791 | |||||||||
| Expr6617 | |||||||||
| Expr15278 | |||||||||
| Expr15293 | |||||||||
| Expr1021911 | |||||||||
| Expr1035052 | |||||||||
| Expr1156136 | |||||||||
| Expr2011320 | |||||||||
| Expr2029556 | |||||||||
| Drives_construct | WBCnstr00002272 | ||||||||
| WBCnstr00010447 | |||||||||
| WBCnstr00030622 | |||||||||
| Construct_product | WBCnstr00030622 | ||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (228) | |||||||||
| Interaction (222) | |||||||||
| Map_info | Map | IV | Position | 4.89065 | |||||
| Positive | Positive_clone | T05E11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
