WormBase Tree Display for Gene: WBGene00011480
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WBGene00011480 | SMap | S_parent | Sequence | T05E11 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | enpl-1 | Person_evidence | WBPerson304 | |||
Sequence_name | T05E11.3 | ||||||
Molecular_name | T05E11.3a | ||||||
T05E11.3a.1 | |||||||
CE06362 | |||||||
T05E11.3b | |||||||
CE45764 | |||||||
T05E11.3a.2 | |||||||
T05E11.3b.1 | |||||||
Other_name | CELE_T05E11.3 | Accession_evidence | NDB | BX284604 | |||
Public_name | enpl-1 | ||||||
DB_info | Database | AceView | gene | 4L887 | |||
WormQTL | gene | WBGene00011480 | |||||
WormFlux | gene | WBGene00011480 | |||||
NDB | locus_tag | CELE_T05E11.3 | |||||
Panther | gene | CAEEL|WormBase=WBGene00011480|UniProtKB=Q22235 | |||||
family | PTHR11528 | ||||||
NCBI | gene | 178014 | |||||
RefSeq | protein | NM_001268607.4 | |||||
NM_001268608.3 | |||||||
SwissProt | UniProtAcc | Q22235 | |||||
TREEFAM | TREEFAM_ID | TF105969 | |||||
UniProt_GCRP | UniProtAcc | Q22235 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | enpl | ||||||
Allele (44) | |||||||
Possibly_affected_by | WBVar02153291 | ||||||
Strain | WBStrain00037295 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (14) | |||||||
Ortholog (38) | |||||||
Paralog | WBGene00000915 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00020110 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | enpl-1 encodes the C. elegans ortholog of the Hsp90 family member and endoplasmic reticulum (ER) chaperone GRP94/GP96; loss of enpl-1 activity via RNAi results in slow growth, larval arrest, uncoordinated locomotion, and weak endocytosis defects; in addition, loss of enpl-1 expression results in an increase in hsp-4 expression, revealing compensatory regulation amongst ER chaperones; an enpl-1::gfp reporter fusion is expressed in the pharynx, with large-scale expression studies reporting additional expression in the intestine and several unidentified cells in the head. | Paper_evidence | WBPaper00003992 | |||
WBPaper00005654 | |||||||
WBPaper00006395 | |||||||
WBPaper00025054 | |||||||
WBPaper00025202 | |||||||
WBPaper00030951 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 15 Oct 2013 00:00:00 | ||||||
Automated_description | Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Expressed in head; neurons; pharynx; and vulva. Human ortholog(s) of this gene implicated in lung adenocarcinoma. Is an ortholog of human HSP90B1 (heat shock protein 90 beta family member 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12028) | ||
Molecular_info | Corresponding_CDS | T05E11.3a | |||||
T05E11.3b | |||||||
Corresponding_transcript | T05E11.3a.1 | ||||||
T05E11.3a.2 | |||||||
T05E11.3b.1 | |||||||
Other_sequence (237) | |||||||
Associated_feature (11) | |||||||
Experimental_info | RNAi_result (14) | ||||||
Expr_pattern | Chronogram787 | ||||||
Expr1791 | |||||||
Expr6617 | |||||||
Expr15278 | |||||||
Expr15293 | |||||||
Expr1021911 | |||||||
Expr1035052 | |||||||
Expr1156136 | |||||||
Expr2011320 | |||||||
Expr2029556 | |||||||
Drives_construct | WBCnstr00002272 | ||||||
WBCnstr00010447 | |||||||
WBCnstr00030622 | |||||||
Construct_product | WBCnstr00030622 | ||||||
Microarray_results (29) | |||||||
Expression_cluster (228) | |||||||
Interaction (222) | |||||||
Map_info | Map | IV | Position | 4.89065 | |||
Positive | Positive_clone | T05E11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (16) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |