WormBase Tree Display for Gene: WBGene00011095

WBGene00011095 SMap: S_parent: Sequence: R07B7
  Identity: Version: 2
    Name: CGC_name: gana-1 Paper_evidence: WBPaper00024919
      Sequence_name: R07B7.11
      Molecular_name: R07B7.11
        R07B7.11.1
        CE06273
      Other_name: CELE_R07B7.11 Accession_evidence: NDB BX284605
      Public_name: gana-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 11 Feb 2005 11:14:24 WBPerson2970 Name_change: CGC_name: gana-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gana
    Allele (28)
    Strain: WBStrain00002061
      WBStrain00033052
      WBStrain00052080
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog: WBGene00052422 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00041740 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00135081 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00209837 Caenorhabditis japonica From_analysis: TreeFam
            WormBase-Compara
      WBGene00099962 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00225530 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g600 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3040 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g21017 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g12057 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g863 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g19862 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g13898 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g699 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g21684 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g14349 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00169.g6114 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_02179.g16959 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-gana-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g10357 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00207.g7044 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_13059 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_018182 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05206 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g22034 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g4320 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g4325 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50135300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g15920 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00243691 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00108596 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00257670 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00290058 Trichuris muris From_analysis: WormBase-Compara
      WBGene00293393 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0032192 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0034117 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-041010-207 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-051113-256 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:4296 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7631 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1347344 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1261422 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1306025 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1589721 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Structured_description: Concise_description: gana-1 encodes a protein with homology to both human alpha-galactosidase (alpha-GAL) and alpha-N-acetylgalactosaminidase (alpha-NAGA) enzymes; these dual enzymatic activities were detected in mixed culture homogenates; immunofluorescence studies show cytoplasmic expression of GANA-1 in body wall muscle and intestinal cells and in coelomocytes. the human gene alpha-galactosidase B (GALB; OMIM:104170), when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency. Paper_evidence: WBPaper00004637
            WBPaper00024995
          Curator_confirmed: WBPerson324
            WBPerson1823
            WBPerson567
          Date_last_updated: 13 Jul 2007 00:00:00
      Automated_description: Predicted to enable alpha-galactosidase activity. Involved in glycoside catabolic process. Located in cytoplasm. Expressed in coelomocyte. Used to study Fabry disease. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schindler disease (multiple); and angiokeratoma. Is an ortholog of human GLA (galactosidase alpha) and NAGA (alpha-N-acetylgalactosaminidase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14499 Homo sapiens Paper_evidence: WBPaper00024995
          Accession_evidence: OMIM 301500
          Curator_confirmed: WBPerson324
          Date_last_updated: 26 Mar 2013 00:00:00
    Potential_model: DOID:14499 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4296)
      DOID:0112318 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7631)
      DOID:479 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7631)
      DOID:0112319 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7631)
      DOID:2367 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7631)
    Disease_relevance: Elegans gana-1 is orthologous to the human NAGA and GALA genes; the human gene Alpha-N-acetylgalactosaminidase (NAGA, also known as GALB) is a lysosomal glycohydrolase, that cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates; mutations in GALB have been associated with Schindler disease type I and III and Kanzaki disease; mutations in human alpha-galactosidase (GLA), a lysosomal hydrolase are associated with Fabry disease. Homo sapiens Paper_evidence: WBPaper00031904
            WBPaper00024995
          Accession_evidence: OMIM 609242
              609241
              301500
              300644
          Curator_confirmed: WBPerson324
          Date_last_updated: 08 May 2013 00:00:00
  Models_disease_in_annotation: WBDOannot00000117
  Molecular_info: Corresponding_CDS: R07B7.11
    Corresponding_transcript: R07B7.11.1
    Other_sequence (42)
    Associated_feature: WBsf661853
      WBsf232594
      WBsf232595
  Experimental_info: RNAi_result: WBRNAi00034684 Inferred_automatically: RNAi_primary
      WBRNAi00017514 Inferred_automatically: RNAi_primary
      WBRNAi00051428 Inferred_automatically: RNAi_primary
      WBRNAi00061279 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1180
      Expr3168
      Expr6474
      Expr6475
      Expr1010714
      Expr1034872
      Expr1155117
      Expr2011940
      Expr2030177
    Drives_construct: WBCnstr00002845
      WBCnstr00004440
      WBCnstr00011188
      WBCnstr00030937
    Construct_product: WBCnstr00011188
      WBCnstr00016579
      WBCnstr00016580
      WBCnstr00030937
    Microarray_results (19)
    Expression_cluster (196)
    Interaction: WBInteraction000123322
      WBInteraction000396593
      WBInteraction000416572
      WBInteraction000504156
      WBInteraction000551639
  Map_info: Map: V Position: 3.62659 Error: 0.001183
    Positive: Positive_clone: R07B7 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00024995
    WBPaper00038491
    WBPaper00042257
    WBPaper00055090
    WBPaper00064161
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene