WormBase Tree Display for Gene: WBGene00010707
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| WBGene00010707 | SMap | S_parent | Sequence | K09A11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cyp-14A3 | |||||||
| Sequence_name | K09A11.4 | ||||||||
| Molecular_name | K09A11.4 | ||||||||
| K09A11.4.1 | |||||||||
| CE03475 | |||||||||
| Other_name | CELE_K09A11.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | cyp-14A3 | ||||||||
| DB_info | Database | AceView | gene | XN890 | |||||
| WormQTL | gene | WBGene00010707 | |||||||
| WormFlux | gene | WBGene00010707 | |||||||
| NDB | locus_tag | CELE_K09A11.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00010707|UniProtKB=Q27507 | |||||||
| family | PTHR24284 | ||||||||
| NCBI | gene | 187185 | |||||||
| RefSeq | protein | NM_077804.4 | |||||||
| TrEMBL | UniProtAcc | Q27507 | |||||||
| UniProt_GCRP | UniProtAcc | Q27507 | |||||||
| OMIM | gene | 610670 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | cyp-14A3 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyp | ||||||||
| Allele (47) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00079915 | ||||||||
| 00079916 | |||||||||
| 00079917 | |||||||||
| 00118055 | |||||||||
| 00118056 | |||||||||
| 00118057 | |||||||||
| 00118058 | |||||||||
| Ortholog (77) | |||||||||
| Paralog (42) | |||||||||
| Structured_description | Concise_description | cyp-14A3 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates; large-scale expression studies reveal cyp-14A3 expression in the intestine and some neurons; cyp-14A3 expression is upregulated in response to the tetrachlorobiphenyl PCB52, benzopyrene, and propanol. | Paper_evidence | WBPaper00029387 | |||||
| WBPaper00031006 | |||||||||
| WBPaper00031939 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Nov 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; hematologic cancer (multiple); and hereditary spastic paraplegia 56. Is an ortholog of several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2W1 (cytochrome P450 family 2 subfamily W member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (12) | ||||||||
| Molecular_info | Corresponding_CDS | K09A11.4 | |||||||
| Corresponding_transcript | K09A11.4.1 | ||||||||
| Associated_feature | WBsf1007581 | ||||||||
| WBsf1024212 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00016861 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00050362 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092634 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114810 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram132 | ||||||||
| Expr6373 | |||||||||
| Expr1027105 | |||||||||
| Expr1154067 | |||||||||
| Expr2010693 | |||||||||
| Expr2028932 | |||||||||
| Drives_construct | WBCnstr00003769 | ||||||||
| WBCnstr00012160 | |||||||||
| WBCnstr00031202 | |||||||||
| Construct_product | WBCnstr00031202 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction | WBInteraction000155642 | ||||||||
| WBInteraction000156226 | |||||||||
| WBInteraction000504562 | |||||||||
| WBInteraction000580719 | |||||||||
| Map_info | Map | X | Position | 11.129 | Error | 0.009754 | |||
| Positive | Positive_clone | K09A11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00029387 | ||||||||
| WBPaper00031529 | |||||||||
| WBPaper00031939 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00038729 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062515 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
