WormBase Tree Display for Gene: WBGene00010706

WBGene00010706 SMap: S_parent: Sequence: K09A11
  Identity: Version: 3
    Name: CGC_name: cyp-14A2
      Sequence_name: K09A11.3
      Molecular_name: K09A11.3
        K09A11.3.1
        CE03474
      Other_name: tag-190 Person_evidence: WBPerson201
        CELE_K09A11.3 Accession_evidence: NDB BX284606
      Public_name: cyp-14A2
    DB_info: Database: AceView gene XN886
        WormQTL gene WBGene00010706
        WormFlux gene WBGene00010706
        NDB locus_tag CELE_K09A11.3
        Panther gene CAEEL|WormBase=WBGene00010706|UniProtKB=Q27505
          family PTHR24284
        NCBI gene 187184
        RefSeq protein NM_077803.4
        TrEMBL UniProtAcc Q27505
        UniProt_GCRP UniProtAcc Q27505
        OMIM gene 610670
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-14A2
        3 06 Oct 2005 10:42:54 WBPerson2970 Event: Acquires_merge: WBGene00007051
              Name_change: Other_name: tag-190
      Acquires_merge: WBGene00007051
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (27)
    Strain: WBStrain00035912
    RNASeq_FPKM (74)
    GO_annotation: 00079908
      00079909
      00079910
      00118051
      00118052
      00118053
      00118054
    Ortholog (76)
    Paralog (42)
    Structured_description: Concise_description: cyp-14A2 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates. Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Nov 2008 00:00:00
      Automated_description: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; hematologic cancer (multiple); and hereditary spastic paraplegia 56. Is an ortholog of several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2W1 (cytochrome P450 family 2 subfamily W member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (12)
  Molecular_info: Corresponding_CDS: K09A11.3
    Corresponding_transcript: K09A11.3.1
    Other_sequence: ACC10519_1
      Acan_isotig16510
      Acan_isotig20860
      PPC14875_1
      ACC19344_1
      ACC37757_1
      FC540658.1
      FC546538.1
      FC544295.1
      Oden_isotig28571
    Associated_feature: WBsf238118
  Experimental_info: RNAi_result: WBRNAi00050361 Inferred_automatically: RNAi_primary
      WBRNAi00081517 Inferred_automatically: RNAi_primary
      WBRNAi00081539 Inferred_automatically: RNAi_primary
      WBRNAi00016860 Inferred_automatically: RNAi_primary
      WBRNAi00034175 Inferred_automatically: RNAi_primary
      WBRNAi00081492 Inferred_automatically: RNAi_primary
      WBRNAi00092633 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8188
      Expr1015820
      Expr1154066
      Expr2010692
      Expr2028931
    Drives_construct: WBCnstr00004994
      WBCnstr00031203
    Construct_product: WBCnstr00031203
    Microarray_results (15)
    Expression_cluster: WBPaper00031040:Cluster_5
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00045401:N.parisii_40h_downregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00046415:lithium_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050121:mir-60(n4947)_downregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050504:hrp-2(RNAi)_downregulated
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051039:intestine_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053020:sid-3(ok973)_downregulated
      WBPaper00053020:sta-1(ok587)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053402:his-3(RNAi)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055137:S.maltophilia_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Psora_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:hif-1(ia4)_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L2
      WBPaper00056169:rrf-3(pk1426)_downregulated_L3
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056284:ints-5(RNAi)_upregulated
      WBPaper00056284:ints-6(t1903)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:flcn-1(ok975)_upregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056586:kri-1(ok1251)_downregulated
      WBPaper00057068:Cadmium_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057196:raga-1(ok386)_upregulated)
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:paraquat_upregulated
      WBPaper00058711:skn-1(lax188)_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059253:sucrose_downregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059754:C.neoformans_H99_upregulated
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060273:isp-1(qm150)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:CoCl2_6hr_downregulated_N2
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060764:swsn-1(os22ts)_downregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061340:RIH
      WBPaper00061340:XXX
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:cyp-14A1-R186.1_5533
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061590:CGP37157_upregulated
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_upregulated
      WBPaper00062146:MOG-7-degron_1h_regulated
      WBPaper00062167:mbl-1(tm1563)_downregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064502:spe-44(fx110)_downregulated
      WBPaper00064509:static-magnetic-field_upregulated
      WBPaper00064532:pals-22(jy3)_downregulated
      WBPaper00064661:lpd-3(ok2138)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_upregulated_starved
      WBPaper00064788:ketamine_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:JU1400_N.ironsii_regulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
      WBPaper00065288:mdt-15(tm2182)_upregulated
      WBPaper00065315:mating_upregulated_Day6-7
      WBPaper00065658:S.ven-metabolite_upregulated_Day7
      WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065841:33_0
      WBPaper00065849:ursolic-acid_regulated
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00027111:rde-3(r459)_downregulated
      WBPaper00034739:N2lessDR1350
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_C
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1up_daf-2nc
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00055899:2,4-Dinitroanisole_regulated
      WBPaper00056330:mrps-5(RNAi)_downregulated
    Interaction: WBInteraction000032180
      WBInteraction000145443
      WBInteraction000155641
      WBInteraction000156225
      WBInteraction000171003
      WBInteraction000580718
  Map_info: Map: X Position: 11.1054 Error: 0.0367
    Positive: Positive_clone: K09A11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5542
        4661
        5082
    Pseudo_map_position
  Reference: WBPaper00031529
    WBPaper00038491
    WBPaper00055090
    WBPaper00062515
    WBPaper00065988
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene